Synthetic gene networks as potential flexible parallel logic gates

被引:47
作者
Ando, Hiroyasu [1 ]
Sinha, Sudeshna [2 ]
Storni, Remo [3 ]
Aihara, Kazuyuki [3 ,4 ]
机构
[1] RIKEN, Brain Sci Inst, Wako, Saitama 3510198, Japan
[2] Indian Inst Sci Educ & Res IISER Mohali, Chandigarh 160019, India
[3] Univ Tokyo, Inst Ind Sci, Meguro Ku, Tokyo 1538505, Japan
[4] Aihara Innovat Math Modelling Project, FIRST, Tokyo, Japan
关键词
NOISE; SWITCHES;
D O I
10.1209/0295-5075/93/50001
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
We show how a synthetic gene network can function, in an optimal window of noise, as a robust logic gate. Interestingly, noise enhances the reliability of the logic operation. Further, the noise level can also be used to switch logic functionality, for instance toggle between AND, OR and XOR gates. We also consider a two-dimensional model of a gene network, where we show how two complementary gate operations can be achieved simultaneously. This indicates the flexible parallel processing potential of this biological system. Copyright (c) EPLA, 2011
引用
收藏
页数:6
相关论文
共 15 条
[1]  
ANNA D, 2011, EPL, V93, P18001
[2]  
Bartee TC, 1991, COMPUTER ARCHITECTUR
[3]  
Chen L., 2010, MOD BIOM NETW CELLS
[4]   A memory device sustained by noise [J].
Fierens, P. I. ;
Ibanez, S. A. ;
Perazzo, R. P. J. ;
Patterson, G. A. ;
Grosz, D. F. .
PHYSICS LETTERS A, 2010, 374 (22) :2207-2209
[5]   Construction of a genetic toggle switch in Escherichia coli [J].
Gardner, TS ;
Cantor, CR ;
Collins, JJ .
NATURE, 2000, 403 (6767) :339-342
[6]   A Noise-Assisted Reprogrammable Nanomechanical Logic Gate [J].
Guerra, Diego N. ;
Bulsara, Adi R. ;
Ditto, William L. ;
Sinha, Sudeshna ;
Murali, K. ;
Mohanty, P. .
NANO LETTERS, 2010, 10 (04) :1168-1171
[7]   Noise-based switches and amplifiers for gene expression [J].
Hasty, J ;
Pradines, J ;
Dolnik, M ;
Collins, JJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (05) :2075-2080
[8]   Designer gene networks: Towards fundamental cellular control [J].
Hasty, J ;
Isaacs, F ;
Dolnik, M ;
McMillen, D ;
Collins, JJ .
CHAOS, 2001, 11 (01) :207-220
[9]  
Mano M. M., 1993, Computer System Architecture
[10]   Realization of reliable and flexible logic gates using noisy nonlinear circuits [J].
Murali, K. ;
Rajamohamed, I. ;
Sinha, Sudeshna ;
Ditto, William L. ;
Bulsara, Adi R. .
APPLIED PHYSICS LETTERS, 2009, 95 (19)