MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine

被引：137

作者：

Bousquet, J. ^{[1
,2
]}

Anto, J. ^{[3
,4
,5
,56
]}

Auffray, C. ^{[6
]}

Akdis, M. ^{[7
]}

Cambon-Thomsen, A. ^{[8
,9
]}

Keil, T. ^{[10
]}

Haahtela, T. ^{[11
]}

Lambrecht, B. N. ^{[12
]}

Postma, D. S. ^{[13
]}

Sunyer, J. ^{[3
,4
,5
,56
]}

Valenta, R. ^{[14
]}

Akdis, C. A. ^{[7
]}

Annesi-Maesano, I. ^{[15
,16
]}

Arno, A. ^{[17
]}

Bachert, C. ^{[18
]}

Ballester, F. ^{[19
]}

Basagana, X. ^{[3
,4
,56
]}

Baumgartner, U. ^{[20
]}

Bindslev-Jensen, C. ^{[21
]}

Brunekreef, B. ^{[22
,23
]}

Carlsen, K. H. ^{[24
,25
]}

Chatzi, L. ^{[26
]}

Crameri, R. ^{[7
]}

Eveno, E. ^{[6
]}

Forastiere, F. ^{[27
]}

Garcia-Aymerich, J. ^{[3
,4
,5
,56
]}

Guerra, S. ^{[3
,4
,28
,56
]}

Hammad, H. ^{[12
]}

Heinrich, J. ^{[29
]}

Hirsch, D. ^{[30
]}

Jacquemin, B. ^{[2
,31
]}

Kauffmann, F. ^{[2
,31
]}

Kerkhof, M. ^{[32
]}

Kogevinas, M. ^{[3
,4
,33
,56
]}

Koppelman, G. H. ^{[34
]}

Kowalski, M. L. ^{[35
]}

Lau, S. ^{[36
]}

Lodrup-Carlsen, K. C. ^{[24
,25
]}

Lopez-Botet, M. ^{[37
]}

Lotvall, J. ^{[39
]}

Lupinek, C. ^{[14
]}

Maier, D. ^{[40
]}

Makela, M. J. ^{[11
]}

Martinez, F. D. ^{[28
]}

Mestres, J. ^{[5
,38
,41
]}

Momas, I. ^{[42
,43
]}

Nawijn, M. C. ^{[44
]}

Neubauer, A. ^{[20
]}

Oddie, S. ^{[45
,46
]}

Palkonen, S. ^{[47
]}

机构：

[1] Hop Arnaud de Villeneuve, Serv Malad Resp, Dept Resp Dis, Univ Hosp, Montpellier 05, France

[2] INSERM, CESP Ctr Res Epidemiol & Populat Hlth, U1018, Resp & Environm Epidemiol Team, Villejuif, France

[3] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain

[4] Municipal Inst Med Res IMIM Hosp del Mar, Barcelona, Spain

[5] UPF, Barcelona, Catalonia, Spain

[6] CNRS Inst Biol Sci, Villejuif, France

[7] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[8] Fac Med Toulouse, INSERM, U558, Epidemiol & Anal Sante Publ Risques Malad Chron &, F-31073 Toulouse, France

[9] Univ Toulouse 3, Fac Med, F-31062 Toulouse, France

[10] Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany

[11] Helsinki Univ Hosp, Dept Dermatol, Skin & Allergy Hosp, Helsinki, Finland

[12] Ghent Univ Hosp, Lab Immunoregulat & Mucosal Immunol, B-9000 Ghent, Belgium

[13] Univ Groningen, Dept Pulmonol, GRIAC Res Inst, Univ Med Ctr Groningen, Groningen, Netherlands

[14] Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Christian Doppler Lab Allergy Res, Div Immunopathol,Dept Pathophysiol & Allergy Res, Vienna, Austria

[15] EPAR U707 INSERM, Paris, France

[16] EPAR UMR S UPMC, Paris, France

[17] Onmed Networks, Barcelona, Spain

[18] Ghent Univ Hosp, URL Upper Airways Res Lab, B-9000 Ghent, Belgium

[19] Univ Valencia, Dept Nursing, Ctr Publ Hlth Res CSISP, Environm & Hlth Area,CIBERESP, Valencia, Spain

[20] Biomay AG, Vienna, Austria

[21] Odense Univ Hosp, DK-5000 Odense, Denmark

[22] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands

[23] Univ Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[24] Univ Oslo, Dept Paediat, Oslo, Norway

[25] Oslo Univ Hosp, Oslo, Norway

[26] Univ Crete, Fac Med, Dept Social Med, Iraklion, Greece

[27] Lazio Reg Hlth Serv, Dept Epidemiol, Rome, Italy

[28] Univ Arizona, Arizona Resp Ctr, Tucson, AZ USA

[29] Helmholtz Zentrum Munchen, Inst Epidemiol, Munich, Germany

[30] Inserm Transfert, Paris, France

[31] Univ Paris 11, UMRS 1018, Villejuif, France

[32] Univ Groningen, Dept Epidemiol, GRIAC Res Inst, Univ Med Ctr Groningen, Groningen, Netherlands

[33] Natl Sch Publ Hlth, Dept Nutr, Athens, Greece

[34] Univ Groningen, Dept Pediat Pulmonol & Pediat Allergol, Beatrix Childrens Hosp, GRIAC Res Inst,Univ Med Ctr Groningen, Groningen, Netherlands

[35] Med Univ Lodz, Dept Immunol Rheumatol & Allergy, Lodz, Poland

[36] Charite Campus Virchow, Dept Pneumol & Immunol, Berlin, Germany

[37] Univ Pompeu Fabra, Immunol Unit, Barcelona, Spain

[38] IMIM Hosp de Mar, Chemotargets SL, Barcelona, Catalonia, Spain

[39] Univ Gothenburg, Gothenburg, Sweden

[40] Biomax Informat AG, Planegg Martinsried, Germany

[41] IMIM Hosp del Mar, Chemogen Lab, GRIB Unit, Barcelona, Catalonia, Spain

[42] Paris Descartes Univ, Dept Publ Hlth & Biostat, EA 4064, Paris, France

[43] Paris Municipal Dept Social Act Childhood & Hlth, Paris, France

[44] Univ Groningen, Lab Allergol & Pulm Dis, Dept Pathol & Med Biol, GRIAC Res Inst,Univ Med Ctr Groningen, Groningen, Netherlands

[45] Bradford Teaching Hosp Fdn Trust, Bradford Inst Hlth Res, Bradford, W Yorkshire, England

[46] Bradford Royal Infirm, Bradford BD9 6RJ, W Yorkshire, England

[47] EFA European Federat Allergy & Airways Dis Patien, Brussels, Belgium

[48] CHU Grenoble, F-38043 Grenoble, France

[49] Univ Grenoble 1, INSERM, U823, Inst Albert Bonniot, Grenoble, France

[50] Univ Hosp Grenoble, Dept Pulmonol, Grenoble, France

来源：

ALLERGY | 2011年 / 66卷 / 05期

关键词：

allergy; early diagnosis; epigenetics; framework programme 7; IgE; mechanisms; mechanisms of the development of allergy; prevention; proteomics; systems medicine; transcriptomics; BIRTH COHORT; ASTHMA; ENVIRONMENT; GENES; VARIANTS; RISK; LIFE;

D O I：

10.1111/j.1398-9995.2010.02534.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

P>The origin of the epidemic of IgE-associated (allergic) diseases is unclear. MeDALL (Mechanisms of the Development of ALLergy), an FP7 European Union project (No. 264357), aims to generate novel knowledge on the mechanisms of initiation of allergy and to propose early diagnosis, prevention, and targets for therapy. A novel phenotype definition and an integrative translational approach are needed to understand how a network of molecular and environmental factors can lead to complex allergic diseases. A novel, stepwise, large-scale, and integrative approach will be led by a network of complementary experts in allergy, epidemiology, allergen biochemistry, immunology, molecular biology, epigenetics, functional genomics, bioinformatics, computational and systems biology. The following steps are proposed: (i) Identification of 'classical' and 'novel' phenotypes in existing birth cohorts; (ii) Building discovery of the relevant mechanisms in IgE-associated allergic diseases in existing longitudinal birth cohorts and Karelian children; (iii) Validation and redefinition of classical and novel phenotypes of IgE-associated allergic diseases; and (iv) Translational integration of systems biology outcomes into health care, including societal aspects. MeDALL will lead to: (i) A better understanding of allergic phenotypes, thus expanding current knowledge of the genomic and environmental determinants of allergic diseases in an integrative way; (ii) Novel diagnostic tools for the early diagnosis of allergy, targets for the development of novel treatment modalities, and prevention of allergic diseases; (iii) Improving the health of European citizens as well as increasing the competitiveness and boosting the innovative capacity of Europe, while addressing global health issues and ethical issues.

引用

页码：596 / 604

页数：9

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