Development and function of CD1d-restricted NKT cells: influence of sphingolipids, SAP and sex

被引：26

作者：

Sandberg, JK ^{[1
]}

Ljunggren, HG ^{[1
]}

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Dept Med, Ctr Infect Med, S-14186 Huddinge, Sweden

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 07期

关键词：

D O I：

10.1016/j.it.2005.05.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer T (NKT) cells are innate-like lymphocytes with immunoregulatory properties. They express an invariant and conserved T-cell receptor that recognizes glycolipids presented by CD1d. Manipulation, activation or loss of NKT cells has profound effects on diverse immune functions and can influence desirable responses to infectious organisms and tumors, as well as undesirable responses to autoantigens. Here, we discuss recent progress in the identification of natural endogenous and exogenous CD1d-presented antigens, the understanding of factors that regulate development of NKT cells in the thymus and of factors that influence their function in the periphery. Clinical implications of these findings are briefly touched on.

引用

页码：347 / 349

页数：3

共 25 条

[1] A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan [J].

Amprey, JL ;

Im, JS ;

Turco, SJ ;

Murray, HW ;

Illarionov, PA ;

Besra, GS ;

Porcelli, SA ;

Späth, GF .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (07) :895-904

[2] A thymic precursor to the NK T cell lineage [J].

Benlagha, K ;

Kyin, T ;

Beavis, A ;

Teyton, L ;

Bendelac, A .

SCIENCE, 2002, 296 (5567) :553-555

[3] Cutting edge: Signaling lymphocytic activation molecule-associated protein controls NKT cell functions [J].

Chung, B ;

Aoukaty, A ;

Dutz, J ;

Terhorst, C ;

Tan, RS .

JOURNAL OF IMMUNOLOGY, 2005, 174 (06) :3153-3157

[4] Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene [J].

Coffey, AJ ;

Brooksbank, RA ;

Brandau, O ;

Oohashi, T ;

Howell, GR ;

Bye, JM ;

Cahn, AP ;

Durham, J ;

Heath, P ;

Wray, P ;

Pavitt, R ;

Wilkinson, J ;

Leversha, M ;

Huckle, E ;

Shaw-Smith, CJ ;

Dunham, A ;

Rhodes, S ;

Schuster, V ;

Porta, G ;

Yin, L ;

Serafini, P ;

Sylla, B ;

Zollo, M ;

Franco, B ;

Bolino, A ;

Seri, M ;

Lanyi, A ;

Davis, JR ;

Webster, D ;

Harris, A ;

Lenoir, G ;

St Basile, GD ;

Jones, A ;

Behloradsky, BH ;

Achatz, H ;

Murken, J ;

Fassler, R ;

Sumegi, J ;

Romeo, G ;

Vaudin, M ;

Ross, MT ;

Meindl, A ;

Bentley, DR .

NATURE GENETICS, 1998, 20 (02) :129-135

[5]

Eberl G, 1999, J IMMUNOL, V163, P4091

[6] Mycobacterial phosphatidylinositol mannoside is a natural antigen for old-restricted T cells [J].

Fischer, K ;

Scotet, E ;

Niemeyer, M ;

Koebernick, H ;

Zerrahn, J ;

Maillet, S ;

Hurwitz, R ;

Kursar, M ;

Bonneville, M ;

Kaufmann, SHE ;

Schaible, UE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (29) :10685-10690

[7] The Src family tyrosine kinase Fyn regulates natural killer T cell development [J].

Gadue, P ;

Morton, N ;

Stein, PL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (08) :1189-1195

[8] NKT cells derive from double-positive thymocytes that are positively selected by CDId [J].

Gapin, L ;

Matsuda, JL ;

Surh, CD ;

Kronenberg, M .

NATURE IMMUNOLOGY, 2001, 2 (10) :971-978

[9] Going both ways: immune regulation via CD1d-dependent NKT cells [J].

Godfrey, DI ;

Kronenberg, M .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (10) :1379-1388

[10] Relevance of sexual dimorphism to regulatory T cells:: estradiol promotes IFN-γ production by invariant natural killer T cells [J].

Gourdy, P ;

Araujo, LM ;

Zhu, R ;

Garmy-Susini, B ;

Diem, S ;

Laurell, H ;

Leite-de-Moraes, M ;

Dy, M ;

Amal, JF ;

Bayard, F ;

Herbelin, A .

BLOOD, 2005, 105 (06) :2415-2420

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