Mutations including IS6110 insertion in the gene encoding the MPB64 protein of capilia TB-negative Mycobacterium tuberculosis isolates

被引：68

作者：

Hirano, K ^{[1
]}

Aono, A

Takahashi, M

Abe, C

机构：

[1] Japan Anti TB Assoc, Res Inst TB, Dept Basic Res, Tokyo 2048533, Japan

[2] Fukujuji Hosp, Dept Clin Lab, Japan Anti TB Assoc, Tokyo 2048533, Japan

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2004年 / 42卷 / 01期

关键词：

D O I：

10.1128/JCM.42.1.390-392.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A simple immunochromatographic assay, Capilia TB, using anti-MPB64 monoclonal antibodies, is a kit for discriminating between the Mycobacterium tuberculosis complex and mycobacteria other than tubercle bacilli. The sensitivity of the kit was estimated to be 99.2% (381 of 384 samples). The sequencing analysis revealed that all of the Capilia TB-negative isolates had mutations within the mpb64 gene, leading to the production of an incomplete protein as a result of a deletion of the C-terminal region of the protein.

引用

页码：390 / 392

页数：3

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