Induction of protective immunity by primed B-1 cells in Toxoplasma gondii-infected B cell-deficient mice

被引：15

作者：

Chen, M

Mun, HS

Piao, LX

Aosai, F

Norose, K

Mohamed, RM

Belal, US

Fang, H

Ahmed, AK

Kang, HK

Matsuzaki, G

Kitamura, D

Yano, A

机构：

[1] Chiba Univ, Grad Sch Med, Dept Infect & Host Def, Chuo Ku, Chiba 2608670, Japan

[2] Univ Ryukyus, Ctr Mol Sci, Div Mol Microbiol, Okinawa 9030215, Japan

[3] Sci Univ Tokyo, Res Inst Biol Sci, Div Mol Biol, Noda, Chiba 2780022, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2003年 / 47卷 / 12期

关键词：

B-1; cells; Toxoplasma gondii; mu MT mice;

D O I：

10.1111/j.1348-0421.2003.tb03460.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the role of B-1 cells in protection against Toxoplasma gondii infection using B cell-deficient mice (muMT mice). We found that primed but not naive B-1 cells from wild-type C57BL/6 mice protected B cell-deficient recipients from challenge infection. All muMT mice transferred with primed B-1 cells survived more than 5 months after T gondii infection, whereas 100% of muMT mice transferred with naive B-1 cells succumbed by 18 days after infection. Additionally, high expression of both T help (Th) 1- and Th2-type cytokines and a high level of nitric oxide production were observed in T gondii-infected muMT mice transferred with primed B-1 cells. Thus, it was clearly demonstrated that B-1 cells play an important role in host protection against T. gondii infection in muMT mice.

引用

页码：997 / 1003

页数：7

共 32 条

[1]

ADAMS LB, 1990, J IMMUNOL, V144, P2725

[2]

Babai B, 1999, CLIN EXP IMMUNOL, V117, P123

[3] CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools [J].