Irritability in pediatric mania and other childhood psychopathology

被引:106
作者
Leibenluft, E [1 ]
Blair, RJR [1 ]
Charney, DS [1 ]
Pine, DS [1 ]
机构
[1] NIMH, Dept Hlth & Human Serv, NIH, Mood & Anxiety Program, Bethesda, MD 20892 USA
来源
ROOTS OF MENTAL ILLNESS IN CHILDREN | 2003年 / 1008卷
关键词
irritability; childhood psychopathology; reactive aggression; childhood mania; bipolar disorder (BPD);
D O I
10.1196/annals.1301.022
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Irritability is an important symptom in childhood psychopathology that has received relatively little research attention. Recent controversy concerning the diagnosis of mania in children has focused attention on how little is known about how to assess irritability in a systematic way, and about its diagnostic associations. For example, subtyping irritability according to course (chronic vs. episodic), precipitants, and family history may facilitate the identification of psychopathology and the study of pathophysiology. While normative and pathologic irritability can be differentiated reliably, the validity of the distinction is unclear. In addition, there is a need for scales designed to measure the severity of irritability in children with mood and anxiety disorders. In order to facilitate research, we propose a definition of irritability from the perspective of affective neuroscience. Because reactive aggression may be a helpful animal model for irritability, we review the neural circuitry mediating this behavior. Behavioral paradigms that evoke frustration, as well as those that assess the ability to inhibit a prepotent motor response, maintain attentional focus, execute response reversal, recognize angry faces, and regulate emotional responses, may be useful in the study of irritability. Examples of such paradigms are described, and the pharmacology of irritability is reviewed briefly.
引用
收藏
页码:201 / 218
页数:18
相关论文
共 110 条
  • [1] CLASSIFICATION OF CHILDRENS PSYCHIATRIC SYMPTOMS - A FACTOR-ANALYTIC STUDY
    ACHENBAC.TM
    [J]. PSYCHOLOGICAL MONOGRAPHS, 1966, 80 (07): : 1 - &
  • [2] Achenbach T.M., 1991, INTEGRATIVE GUIDE 19
  • [3] INFLUENCE OF TARGET SEX AND DOMINANCE ON EVOKED ATTACK IN RHESUS-MONKEYS
    ALEXANDER, M
    PERACHIO, AA
    [J]. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 1973, 38 (02) : 543 - 547
  • [4] Impairment of social and moral behavior related to early damage in human prefrontal cortex
    Anderson, SW
    Bechara, A
    Damasio, H
    Tranel, D
    Damasio, AR
    [J]. NATURE NEUROSCIENCE, 1999, 2 (11) : 1032 - 1037
  • [5] Puberty and depression: the roles of age, pubertal status and pubertal timing
    Angold, A
    Costello, EJ
    Worthman, CM
    [J]. PSYCHOLOGICAL MEDICINE, 1998, 28 (01) : 51 - 61
  • [6] [Anonymous], 2000, DIAGN STAT MAN MENT
  • [7] AVERILL J, 1982, ANGER AGRESSION ESSA
  • [8] AXELSON D, IN PRESS J CHILD ADO
  • [9] BANDLER R, 1988, PROGR PSYCHOBIOLOGY, V14, P135
  • [10] The amygdala and reward
    Baxter, MG
    Murray, EA
    [J]. NATURE REVIEWS NEUROSCIENCE, 2002, 3 (07) : 563 - 573