The diverse functions of histone lysine methylation

被引：1629

作者：

Martin, C ^{[1
]}

Zhang, Y ^{[1
]}

机构：

[1] Univ N Carolina, Howard Hughes Med Inst, Dept Biochem & Biophys, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1761

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Covalent modifications of histone tails have fundamental roles in chromatin structure and function. One such modification, lysine methylation, has important functions in many biological processes that include heterochromatin formation, X-chromosome inactivation and transcriptional regulation. Here, we summarize recent advances in our understanding of how lysine methylation functions in these diverse biological processes, and raise questions that need to be addressed in the future.

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页码：838 / 849

页数：12

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