B cell memory and the long-lived plasma cell

被引:189
作者
McHeyzer-Williams, MG [1 ]
Ahmed, R
机构
[1] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA
[2] Emory Univ, Sch Med, Dept Microbiol & Immunol, Emory Vaccine Ctr, Atlanta, GA 30322 USA
关键词
D O I
10.1016/S0952-7915(99)80029-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The germinal center reaction is pivotal to the induction of B cell memory. The signals that regulate this complex microenvironment, with their cellular and molecular consequences, underpin long-term protective immunity. Recent studies have identified many key regulators of the germinal center cycle and have revealed an array of cellular outcomes that further define the memory B cell compartment.
引用
收藏
页码:172 / 179
页数:8
相关论文
共 76 条
  • [1] Effect of transmembrane and cytoplasmic domains of IgE on the IgE response
    Achatz, G
    Nitschke, L
    Lamers, MC
    [J]. SCIENCE, 1997, 276 (5311) : 409 - 411
  • [2] Immunological memory and protective immunity: Understanding their relation
    Ahmed, R
    Gray, D
    [J]. SCIENCE, 1996, 272 (5258) : 54 - 60
  • [3] Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate
    Batista, FD
    Neuberger, MS
    [J]. IMMUNITY, 1998, 8 (06) : 751 - 759
  • [4] B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
    Borriello, F
    Sethna, MP
    Boyd, SD
    Schweitzer, AN
    Tivol, EA
    Jacoby, D
    Strom, TB
    Simpson, EM
    Freeman, GJ
    Sharpe, AH
    [J]. IMMUNITY, 1997, 6 (03) : 303 - 313
  • [5] Nuclear factor (NF)-κB2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses
    Caamaño, JH
    Rizzo, CA
    Durham, SK
    Barton, DS
    Raventós-Suárez, C
    Snapper, CM
    Bravo, R
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (02) : 185 - 196
  • [6] Mismatch repair co-opted by hypermutation
    Cascalho, M
    Wong, J
    Steinberg, C
    Wabl, M
    [J]. SCIENCE, 1998, 279 (5354) : 1207 - 1210
  • [7] CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells
    Cerutti, A
    Schaffer, A
    Shah, S
    Zan, H
    Liou, HC
    Goodwin, RG
    Casali, P
    [J]. IMMUNITY, 1998, 9 (02) : 247 - 256
  • [8] Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
    Cornall, RJ
    Cyster, JG
    Hibbs, ML
    Dunn, AR
    Otipoby, KL
    Clark, EA
    Goodnow, CC
    [J]. IMMUNITY, 1998, 8 (04) : 497 - 508
  • [9] DEFINING SUBSETS OF NAIVE AND MEMORY B-CELLS BASED ON THE ABILITY OF THEIR PROGENY TO SOMATICALLY MUTATE IN-VITRO
    DECKER, DJ
    LINTON, PJ
    ZAHAREVITZ, S
    BIERY, M
    GINGERAS, TR
    KLINMAN, NR
    [J]. IMMUNITY, 1995, 2 (02) : 195 - 203
  • [10] Induction of somatic mutation in a human B cell line in vitro
    Denepoux, S
    Razanajaona, D
    Blanchard, D
    Meffre, G
    Capra, JD
    Banchereau, J
    Lebecque, S
    [J]. IMMUNITY, 1997, 6 (01) : 35 - 46