The colorful history of active DNA demethylation

被引：410

作者：

Ooi, Steen K. T. ^{[1
]}

Bestor, Timothy H. ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA

来源：

CELL | 2008年 / 133卷 / 07期

关键词：

D O I：

10.1016/j.cell.2008.06.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Patterns of DNA cytosine methylation are subject to mitotic inheritance in both plants and vertebrates. Plants use 5-methylcytosine glycosylases and the base excision repair pathway to remove excess cytosine methylation. In mammals, active demethylation has been proposed to operate via several very different mechanisms. Two recent reports in Nature now claim that the demethylation process is initiated by the same enzymes that establish the methylation mark, the DNA methyltransferases DNMT3A and DNMT3B (Kangaspeska et al., 2008; Metivier et al., 2008).

引用

页码：1145 / 1148

页数：4

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