High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas

被引:55
作者
Gururangan, S
McLaughlin, C
Quinn, J
Rich, J
Reardon, D
Halperin, EC
Herndon, J
Fuchs, H
George, T
Provenzale, J
Watral, M
McLendon, RE
Friedman, A
Friedman, HS
Kurtzberg, J
Vredenbergh, J
Martin, PL
机构
[1] Duke Univ, Med Ctr, Brain Tumor Ctr, DUMC, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA
[3] Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA
[4] Duke Univ, Med Ctr, Dept Neurol, Durham, NC 27710 USA
[5] Duke Univ, Med Ctr, Dept Neurosurg, Durham, NC 27710 USA
[6] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA
[7] Duke Univ, Med Ctr, Dept Neuroradiol, Durham, NC 27710 USA
[8] Duke Univ, Med Ctr, Dept Family & Community Med, Durham, NC 27710 USA
[9] Duke Univ, Med Ctr, Dept Bone Marrow Transplant, Durham, NC 27710 USA
关键词
D O I
10.1200/JCO.2003.10.096
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose : We evaluated the usefulness of a treatment regimen that included high-dose chemotherapy (HDC) with autologous stem-cell rescue (ASCR) in patients with newly diagnosed pineoblastoma (PBL). Patients and Methods: Twelve patients with PBL were initially treated with surgery and induction chemotherapy. All but two patients underwent radiotherapy. Subsequently, all patients received HDC using cyclophosphamide (CTX) + melphalan (MEL) or busulfan (Bu) + MEL regimens and ASCR. Results: A total of six children and six adults with median ages of 4.2 (range, 0.3 to 19.8 years) and 23 years (range, 23 to 43.7 years), respectively, were treated according to this strategy. Four patients had metastatic disease confined to the neuraxis. Five of 12 patients (42%) had a complete tumor resection at diagnosis. Ten patients received radiotherapy at median doses of 36.0 and 59.4 Gy to the neuraxis and pineal region, respectively. Eleven patients received HDC with CTX + MEL, and one patient received BU + MEL followed by ASCR. Nine patients are alive with no evidence of disease recurrence at a median of 62 months from diagnosis (range, 28 to 125 months), including three patients with metastatic disease and two infants who did not receive any radiotherapy. Three patients have died of progressive disease at 19, 32, and 37 months from diagnosis, respectively. The actuarial 4-year progression-free and overall survivals are 69% (95% confidence interval [CI], 39% to 99%) and 71% (95% Cl, 43% to 99%), respectively. Conclusion: The use of HDC in addition to radiotherapy seems to be an effective treatment for patients with newly diagnosed pineoblastoma. (C) 2003 by American Society of Clinical Oncology.
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收藏
页码:2187 / 2191
页数:5
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