Transformed follicular non-Hodgkin lymphoma

被引：146

作者：

Casulo, Carla ^{[1
]}

Burack, W. Richard ^{[2
]}

Friedberg, Jonathan W. ^{[1
]}

机构：

[1] Univ Rochester, Wilmot Canc Inst, Med Ctr, Div Hematol & Oncol, Rochester, NY 14642 USA

[2] Univ Rochester, Wilmot Canc Inst, Med Ctr, Dept Pathol, Rochester, NY 14642 USA

来源：

BLOOD | 2015年 / 125卷 / 01期

关键词：

B-CELL LYMPHOMA; HIGH-DOSE THERAPY; LONG-TERM SURVIVAL; PHASE-II TRIAL; HISTOLOGICAL TRANSFORMATION; BONE-MARROW; SOMATIC HYPERMUTATION; INDEPENDENT PREDICTOR; IBRITUMOMAB TIUXETAN; NATURAL-HISTORY;

D O I：

10.1182/blood-2014-04-516815

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Histologic transformation of follicular lymphoma to an aggressive non-Hodgkin lymphoma is a critical biologic event with profound implications on the natural history of this otherwise indolent disease. Recent insights into the genetic and epigenetic basis of transformation have been described, with the recognition of pivotal events governing the initiation and persistence of tumor evolution. Outcomes of patients with transformed lymphoma have historically been poor; however, several studies in the rituximab era suggest that survival may be more favorable than previously recognized. This review highlights our current understanding of transformed follicular lymphoma biology and pathogenesis, current treatment, and future directions.

引用

页码：40 / 47

页数：8

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