Aromatic hydrogen bond in sequence-specific protein DNA recognition

被引：69

作者：

Parkinson, G

Gunasekera, A

Vojtechovsky, J

Zhang, XP

Kunkel, TA

Berman, H

Ebright, RH

机构：

[1] RUTGERS STATE UNIV, DEPT CHEM, NEW BRUNSWICK, NJ 08855 USA

[2] RUTGERS STATE UNIV, WAKSMAN INST, NEW BRUNSWICK, NJ 08855 USA

[3] NIEHS, NIH, RES TRIANGLE PK, NC 27709 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 10期

关键词：

D O I：

10.1038/nsb1096-837

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An aromatic hydrogen bond-an interaction between the pi-electron cloud of an aromatic ring and a hydrogen-bond donor-can substitute for a conventional hydrogen bond in sequence-specific protein-DNA interactions and can contribute 0.5-1 kcal mol(-1) to binding and 1-2 kcal mol(-1) to specificity.

引用

收藏

页码：837 / 841

页数：5

相关论文

共 28 条

[1] X-RAY-DIFFRACTION EVIDENCE FOR AROMATIC PI HYDROGEN-BONDING TO WATER [J].

ATWOOD, JL ;

HAMADA, F ;

ROBINSON, KD ;

ORR, GW ;

VINCENT, RL .

NATURE, 1991, 349 (6311) :683-684

[2] CRYSTAL-CHEMISTRY OF TETRARADIAL SPECIES .4. HYDROGEN-BONDING TO AROMATIC PI-SYSTEMS - CRYSTAL-STRUCTURES OF 15 TETRAPHENYLBORATES WITH ORGANIC AMMONIUM CATIONS [J].

BAKSHI, PK ;

LINDEN, A ;

VINCENT, BR ;

ROE, SP ;

ADHIKESAVALU, D ;

CAMERON, TS ;

KNOP, O .

CANADIAN JOURNAL OF CHEMISTRY, 1994, 72 (05) :1273-1293

[3] SELECTION OF DNA-BINDING SITES BY REGULATORY PROTEINS .2. THE BINDING-SPECIFICITY OF CYCLIC-AMP RECEPTOR PROTEIN TO RECOGNITION SITES [J].

BERG, OG ;

VONHIPPEL, PH .

JOURNAL OF MOLECULAR BIOLOGY, 1988, 200 (04) :709-723

[4]

Brunger A.T., 1992, X-Plor Manual Version 3.1

[5]

BURLEY SK, 1988, ADV PROTEIN CHEM, V39, P125

[6] AMINO-AROMATIC INTERACTIONS IN PROTEINS [J].

BURLEY, SK ;

PETSKO, GA .

FEBS LETTERS, 1986, 203 (02) :139-143

[7] CONSENSUS DNA SITE FOR THE ESCHERICHIA-COLI CATABOLITE GENE ACTIVATOR PROTEIN (CAP) - CAP EXHIBITS A 450-FOLD HIGHER AFFINITY FOR THE CONSENSUS DNA SITE THAN FOR THE ESCHERICHIA-COLI LAC DNA SITE [J].

EBRIGHT, RH ;

EBRIGHT, YW ;

GUNASEKERA, A .

NUCLEIC ACIDS RESEARCH, 1989, 17 (24) :10295-10305

[8] MUTATIONS THAT ALTER THE DNA-SEQUENCE SPECIFICITY OF THE CATABOLITE GENE ACTIVATOR PROTEIN OF ESCHERICHIA-COLI [J].

EBRIGHT, RH ;

COSSART, P ;

GICQUELSANZEY, B ;

BECKWITH, J .

NATURE, 1984, 311 (5983) :232-235

[9] ROLE OF GLUTAMIC ACID-181 IN DNA-SEQUENCE RECOGNITION BY THE CATABOLITE GENE ACTIVATOR PROTEIN (CAP) OF ESCHERICHIA-COLI - ALTERED DNA-SEQUENCE-RECOGNITION PROPERTIES OF [VAL181]CAP AND [LEU181]CAP [J].

EBRIGHT, RH ;

KOLB, A ;

BUC, H ;

KUNKEL, TA ;

KRAKOW, JS ;

BECKWITH, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (17) :6083-6087

[10]

EBRIGHT RH, 1991, METHOD ENZYMOL, V208, P620