Stem Cell Response to Multiwalled Carbon Nanotube-Incorporated Regenerated Silk Fibroin Films

被引：16

作者：

Cho, Se Youn ^{[1
]}

Yun, Young Soo ^{[1
]}

Kim, E. Sle ^{[2
]}

Kim, Moon Suk ^{[2
]}

Jin, Hyoung-Joon ^{[1
]}

机构：

[1] Inha Univ, Dept Polymer Sci & Engn, Inchon 402751, South Korea

[2] Ajou Univ, Dept Mol Sci & Technol, Suwon 443749, South Korea

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2011年 / 11卷 / 01期

关键词：

Silk Fibroin; Carbon Nanotube; Nanocomposite; Toxicity; BOMBYX-MORI SILK; COMPOSITES; TOXICOLOGY; FIBERS;

D O I：

10.1166/jnn.2011.3181

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Multiwalled carbon nanotubes (MWCNTs) are considered to be the ideal reinforcements for bio-related applications on account of their remarkable structural, mechanical and thermal properties. However, before MWCNTs can be incorporated into new and existing biomedical devices, their toxicity and biocompatibility need to be investigated thoroughly. In this study, regenerated silk fibroin/MWCNT nanocomposite films were prepared using a solvent system with pre-dispersed MWCNTs. Their biocompatibility was examined in vitro using human bone marrow stem cells. Scanning electron microscopy and a WST-1 assay demonstrated that the silk fibroin/MWCN film supported BMSC attachment and growth over 7 days in culture similar to the silk fibroin only film.

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收藏

页码：801 / 805

页数：5

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