Mucinous ovarian tumors associated with pseudomyxoma peritonei of adenomucinosis type: immunohistochemical evidence that they are secondary tumors

被引:35
作者
Ferreira, C. R. [2 ]
Carvalho, J. P. [1 ]
Soares, F. A. [3 ]
Siqueira, S. A. C. [4 ]
Carvalho, F. M. [2 ]
机构
[1] Univ Sao Paulo, Sch Med, Dept Gynecol, Dept Obstet & Gynecol, BR-01380000 Sao Paulo, Brazil
[2] Univ Sao Paulo, Sch Med, Dept Pathol, BR-01380000 Sao Paulo, Brazil
[3] Hosp Canc AC Camargo, Dept Pathol, Sao Paulo, Brazil
[4] Univ Sao Paulo, Sch Med, Div Surg Pathol, Sao Paulo, Brazil
关键词
appendix; epithelial tumors; immunohistochemistry; intestinal type tumors; mucinous tumors; ovarian tumors; pseudomyxoma peritonei; tissue-microarray;
D O I
10.1111/j.1525-1438.2007.00988.x
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
Pseudomyxoma peritonei (PMP) is a clinical condition initially thought to be related to ovarian mucinous tumors; however, immunohistochemistry and molecular biology techniques have convincingly made the link to appendiceal mucinous neoplasms, resulting in changes in histologic and clinical approaches. The objective of this study was to compare the immunohistochemical profile of ovarian tumors associated with PMP and intestinal mucinous ovarian neoplasms without PMP. The study was retrospective and included 28 intestinal ovarian mucinous tumors selected from the files of the Division of Surgical Pathology of the University of Sao Paulo Medical School, from 1996 to 2005. Seven cases were associated with PMP of disseminated peritoneal adenomucinosis-type and all presented borderline histology. Immunohistochemical staining for mucin genes products (MUC1, MUC2, MUC5AC, and MUC6), CK7, CK20, CA19.9, and CA125 were performed in tissue microarrays. Of note, we detected differences in the expression of MUC2 and CK20 between cases with and without PMP. Comparisons of borderline histology with that of benign/malignant tumors also revealed differences in MUC2 and CK20. Our results confirm that there is a distinct profile of intestinal ovarian tumors associated with pseudomyxoma, particularly with respect to the expression of the gel-forming mucin MUC2. The profile of borderline tumors, even in cases without PMP, was distinct from that of other primary mucinous tumors of the intestinal type, suggesting that borderline histology may represent a secondary tumor or a less aggressive variant of PMP. An appendiceal origin seems the most probable for this group of neoplasias.
引用
收藏
页码:59 / 65
页数:7
相关论文
共 35 条
[1]
Differential expression of MUC2 and MUC5AC mucin genes in primary ovarian and metastatic colonic carcinoma [J].
Albarracin, CT ;
Jafri, J ;
Montag, AG ;
Hart, J ;
Kuan, SF .
HUMAN PATHOLOGY, 2000, 31 (06) :672-677
[2]
Pseudomyxoma peritonei of appendiceal origin: A clinicopathologic analysis of 101 patients uniformly treated at a single institution, with literature review [J].
Bradley, RF ;
Stewart, JH ;
Russell, GB ;
Levine, EA ;
Geisinger, KR .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2006, 30 (05) :551-559
[3]
Synchronous mucinous tumors of the appendix and the ovary associated with pseudomyxoma peritonei - A clinicopathologic study of six cases with comparative analysis of c-Ki-ras mutations [J].
Cuatrecasas, M ;
MatiasGuiu, X ;
Prat, J .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (06) :739-746
[4]
The MUC family:: an obituary [J].
Dekker, J ;
Rossen, JWA ;
Büller, HA ;
Einerhand, AWC .
TRENDS IN BIOCHEMICAL SCIENCES, 2002, 27 (03) :126-131
[5]
Expression of MUC1 and MUC2 mucin gene products in human ovarian carcinomas [J].
Feng, H ;
Ghazizadeh, M ;
Konishi, H ;
Araki, T .
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2002, 32 (12) :525-529
[6]
Mucin genes expressed by human female reproductive tract epithelia [J].
Gipson, IK ;
Ho, SB ;
SpurrMichaud, SJ ;
Tisdale, AS ;
Zhan, Q ;
Torlakovic, E ;
Pudney, J ;
Anderson, DJ ;
Toribara, NW ;
Hill, JA .
BIOLOGY OF REPRODUCTION, 1997, 56 (04) :999-1011
[7]
Mucinous tumors of the vermiform appendix and ovary, and pseudomyxoma peritonei: Histogenetic implications of cytokeratin 7 expression [J].
Guerrieri, C ;
Franlund, B ;
Fristedt, S ;
Gillooley, JF ;
Boeryd, B .
HUMAN PATHOLOGY, 1997, 28 (09) :1039-1045
[8]
Pseudomyxoma peritonei: a case series and review of the literature [J].
Hopkins, M. L. ;
Depetrillo, A. D. ;
Le, T. ;
Fung, M. Fung Kee .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2005, 15 (01) :32-36
[9]
Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites [J].
Lau, SK ;
Weiss, LM ;
Chu, PG .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2004, 122 (01) :61-69
[10]
Expression of mucins and cytokeratins in primary carcinomas of the digestive system [J].
Lee, MJ ;
Lee, HS ;
Kim, WH ;
Choi, Y ;
Yang, MH .
MODERN PATHOLOGY, 2003, 16 (05) :403-410