Diterpenoids from the stem barks of Croton robustus

被引：21

作者：

Ngamrojnavanich, N

Tonsiengsom, S

Lertpratchya, P

Roengsumran, S

Puthong, S

Petsom, A ^{[1
]}

机构：

[1] Chulalongkorn Univ, Inst Biotechnol & Genet Engn, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Fac Sci, Dept Chem, Res Ctr Bioorgan Chem, Bangkok 10330, Thailand

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2003年 / 26卷 / 11期

关键词：

Croton robustus; trachyloban-19-oic acid; trachyloban-19-ol; poilaneic acid; cytotoxic activity;

D O I：

10.1007/BF02980196

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Three compounds were isolated from the stem barks of Croton robustus. Their structures were elucidated as trachyloban-19-oic acid, trachyloban-19-ol and poilaneic acid by spectroscopic analysis. Among them, trachyloban-19-ol and methyl trachyloban-19-oate exhibited weak cytotoxic activity against gastric carcinoma and colon carcinoma with ED50 of 9.2, 9.6 and 8.3, 9.1 mug/mL, respectively.

引用

页码：898 / 901

页数：4

共 13 条

[1]

AMONE A, 1979, ORG MAGN RESONANCE, V12, P429

[2]

Diterpenes and synthetic derivatives from Viguiera aspillioides with trypanomicidal activity [J].