HIV - Cross-talk and viral reservoirs

被引:12
作者
Pomerantz, RJ [1 ]
机构
[1] Thomas Jefferson Univ, Ctr Human Virol & Biodef, Div Infect Dis & Environm Med, Philadelphia, PA 19107 USA
关键词
D O I
10.1038/424136a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Even after intensive antiviral treatment, HIV-1 can lurk in reservoirs in the human body and then reappear. The complex pathways by which the virus creates such reservoirs are only now becoming clear.
引用
收藏
页码:136 / 137
页数:2
相关论文
共 14 条
[1]   Modalities of interleukin-7-induced human immunodeficiency virus permissiveness in quiescent T lymphocytes [J].
Ducrey-Rundquist, O ;
Guyader, M ;
Trono, D .
JOURNAL OF VIROLOGY, 2002, 76 (18) :9103-9111
[2]   Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy [J].
Finzi, D ;
Hermankova, M ;
Pierson, T ;
Carruth, LM ;
Buck, C ;
Chaisson, RE ;
Quinn, TC ;
Chadwick, K ;
Margolick, J ;
Brookmeyer, R ;
Gallant, J ;
Markowitz, M ;
Ho, DD ;
Richman, DD ;
Siliciano, RF .
SCIENCE, 1997, 278 (5341) :1295-1300
[3]   IMPORTANCE OF THE NEF GENE FOR MAINTENANCE OF HIGH VIRUS LOADS AND FOR DEVELOPMENT OF AIDS [J].
KESTLER, HW ;
RINGLER, DJ ;
MORI, K ;
PANICALI, DL ;
SEHGAL, PK ;
DANIEL, MD ;
DESROSIERS, RC .
CELL, 1991, 65 (04) :651-662
[4]   BRIEF REPORT - ABSENCE OF INTACT NEF SEQUENCES IN A LONG-TERM SURVIVOR WITH NONPROGRESSIVE HIV-1 INFECTION [J].
KIRCHHOFF, F ;
GREENOUGH, TC ;
BRETTLER, DB ;
SULLIVAN, JL ;
DESROSIERS, RC .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (04) :228-232
[5]   Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy [J].
Kulkosky, J ;
Nunnari, G ;
Otero, M ;
Calarota, S ;
Dornadula, G ;
Zhang, H ;
Malin, A ;
Sullivan, J ;
Xu, Y ;
DeSimone, J ;
Babinchak, T ;
Stern, J ;
Cavert, W ;
Haase, A ;
Pomerantz, RJ .
JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (10) :1403-1411
[6]   Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection [J].
Pierson, TC ;
Zhou, Y ;
Kieffer, TL ;
Ruff, CT ;
Buck, C ;
Siliciano, RF .
JOURNAL OF VIROLOGY, 2002, 76 (17) :8518-8531
[7]   Residual HIV-1 infection during antiretroviral therapy: the challenge of viral persistence [J].
Pomerantz, RJ .
AIDS, 2001, 15 (10) :1201-1211
[8]   HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages [J].
Swingler, S ;
Mann, A ;
Jacqué, JM ;
Brichacek, B ;
Sasseville, VG ;
Williams, K ;
Lackner, AA ;
Janoff, EN ;
Wang, R ;
Fisher, D ;
Stevenson, M .
NATURE MEDICINE, 1999, 5 (09) :997-1003
[9]   HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection [J].
Swingler, S ;
Brichacek, B ;
Jacque, JM ;
Ulich, C ;
Zhou, J ;
Stevenson, M .
NATURE, 2003, 424 (6945) :213-219
[10]   Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes [J].
Unutmaz, D ;
KewalRamani, VN ;
Marmon, S ;
Littman, DR .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (11) :1735-1746