Requirement for membrane lipid peroxidation in HIV-1 gp120-induced neuroblastoma cell death

被引:19
作者
Corasaniti, MT [1 ]
Navarra, M
Nisticò, S
Rotiroti, D
Maccarrone, M
Melino, G
Finazzi-Agrò, A
机构
[1] Univ Catanzaro, Fac Pharm, I-88021 Roccelletta Di Borgia, CZ, Italy
[2] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy
[3] IDI, IRCCS, Rome, Italy
关键词
HIV-1; gp120; neuroblastoma cell death; membrane lipid peroxidation; U-74389G;
D O I
10.1006/bbrc.1998.8687
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The HIV-1 envelope protein gp120 engenders Ca2+-mediated, excitotoxic damage of rodent neuronal and human neuroblastoma cells in culture. Here we report that human CHP100 neuroblastoma cells undergo early peroxidation of membrane lipids following a brief exposure to gp120. This effect is prevented by preincubating cell cultures with the 21-aminosteroid U-74389G, an inhibitor of membrane lipid peroxidation, which also rescues neuroblastoma cultures from gp120-induced cell death; conversely, no protection from cell death is observed when the 21-aminosteroid is added to neuroblastoma cultures after the induction of membrane lipid peroxidation by gp120. These data indicate that membrane lipid peroxidation has a causative role in the expression of cell death produced by the viral protein. (C) 1998 Academic Press.
引用
收藏
页码:686 / 689
页数:4
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