Identifying molecular markers for the early detection of pancreatic neoplasia

被引：88

作者：

Goggins, Michael

机构：

[1] Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Inst, Dept Pathol, Baltimore, MD 21231 USA

[2] Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Inst, Dept Med, Baltimore, MD 21231 USA

[3] Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Inst, Dept Oncol, Baltimore, MD 21231 USA

来源：

SEMINARS IN ONCOLOGY | 2007年 / 34卷 / 04期

关键词：

MACROPHAGE INHIBITORY CYTOKINE-1; PAPILLARY MUCINOUS NEOPLASMS; DIFFERENTIALLY EXPRESSED GENES; MITOCHONDRIAL-DNA MUTATIONS; TUMOR-STROMAL INTERACTIONS; FINE-NEEDLE-ASPIRATION; HIGH-RISK INDIVIDUALS; TGF-BETA SUPERFAMILY; K-RAS MUTATIONS; DUCTAL ADENOCARCINOMA;

D O I：

10.1053/j.seminoncol.2007.05.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer is the fourth most common cause of cancer death in the United States. There is a great need for better diagnostic markers of pancreatic neoplasia. Better markers would improve the early diagnosis of pancreatic cancer and allow more patients to undergo curative surgical resection. Identifying individuals at high risk of developing pancreatic cancer and applying markers that could identify precancerous lesions of the pancreas in these individuals could allow such lesions to be resected before the development of pancreatic cancer. As we continue to characterize the genetic, epigenetic, and proteomics alterations that occur in pancreatic cancers and their percursors, better diagnostic markers of pancreatic cancer are expected to follow. © 2007 Elsevier Inc. All rights reserved.

引用

页码：303 / 310

页数：8

共 139 条

[1] Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1 [J].

Albertoni, M ;

Shaw, PH ;

Nozaki, M ;

Godard, S ;

Tenan, M ;

Hamou, MF ;

Fairlie, DW ;

Breit, SN ;

Paralkar, VM ;

de Tribolet, N ;

Van Meir, EG ;

Hegi, ME .

ONCOGENE, 2002, 21 (27) :4212-4219

[2]

*AM GASTR ASS, 1999, GASTROENTEROLOGY, V117, P1463

[3]

Argani P, 2001, CLIN CANCER RES, V7, P3862

[4] Signal in noise: Evaluating reported reproducibility of serum proteomic tests for ovarian cancer [J].

Baggerly, KA ;

Morris, JS ;

Edmonson, SR ;

Coombes, KR .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (04) :307-309

[5] Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments [J].

Baggerly, KA ;

Morris, JS ;

Coombes, KR .

BIOINFORMATICS, 2004, 20 (05) :777-U710

[6] Mutational analysis of the tyrosine kinome in colorectal cancers [J].

Bardelli, A ;

Parsons, DW ;

Silliman, N ;

Ptak, J ;

Szabo, S ;

Saha, S ;

Markowitz, S ;

Willson, JKV ;

Parmigiani, G ;

Kinzler, KW ;

Vogelstein, B ;

Velculescu, VE .

SCIENCE, 2003, 300 (5621) :949-949

[7]

Berger DH, 1999, CANCER, V85, P326, DOI 10.1002/(SICI)1097-0142(19990115)85:2<326::AID-CNCR9>3.0.CO

[8]

2-O

[9] Diagnosis of pancreatic cancer using serum proteomic profiling [J].

Bhattacharyya, S ;

Siegel, ER ;

Petersen, GM ;

Chari, ST ;

Suva, LJ ;

Haun, RS .

NEOPLASIA, 2004, 6 (05) :674-686

[10] MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily [J].

Bootcov, MR ;

Bauskin, AR ;

Valenzuela, SM ;

Moore, AG ;

Bansal, M ;

He, XY ;

Zhang, HP ;

Donnellan, M ;

Mahler, S ;

Pryor, K ;

Walsh, BJ ;

Nicholson, RC ;

Fairlie, WD ;

Por, SB ;

Robbins, JM ;

Breit, SN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (21) :11514-11519

← 1 2 3 4 5 6 7 8 9 10 →