Understanding the influence of MgO and SrO binary doping on the mechanical and biological properties of β-TCP ceramics

被引：145

作者：

Banerjee, Shashwat S. ^{[1
]}

Tarafder, Solaiman ^{[1
]}

Davies, Neal M. ^{[2
]}

Bandyopadhyay, Amit ^{[1
]}

Bose, Susmita ^{[1
]}

机构：

[1] Washington State Univ, Sch Mech & Mat Engn, WM Keck Biomed Mat Res Lab, Pullman, WA 99164 USA

[2] Washington State Univ, Coll Pharm, Dept Pharmaceut Sci, Pullman, WA 99164 USA

来源：

ACTA BIOMATERIALIA | 2010年 / 6卷 / 10期

基金：

美国国家卫生研究院;

关键词：

beta-Tricalcium phosphate; MgO doping; SrO doping; In vivo behavior; Biocompatibility; TRICALCIUM PHOSPHATE CERAMICS; SINTERING ADDITIVES; RESORBABLE CERAMICS; IN-VITRO; HYDROXYAPATITE; MAGNESIUM; STRONTIUM; BONE; DENSIFICATION; BIOCERAMICS;

D O I：

10.1016/j.actbio.2010.05.012

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The objective of this study was to evaluate the influence of MgO and SrO doping on the mechanical and biological properties of beta-tricalcium phosphate (beta-TCP). beta-TCP was doped with two different binary compositions, 0.25 and 1.0 wt % SrO along with 1.0 wt % MgO MgO and SrO doping increased the beta phase stability at a sintering temperature of 1250 degrees C and marginally decreased the compressive strength of beta-TCP An in vitro cell-material interaction study, using human fetal osteoblast cells (hFOB), indicated that doped beta-TCP was non-toxic, and MgO/SrO dopants improved cell attachment and growth. beta-TCP Implants doped with 1.0 wt.% MgO and 1.0 wt.% SrO showed good in vivo biocompatibility when tested in male Sprague-Dawley rats for 16 weeks Histomorphology analysis indicated that MgO/SrO-doped beta-TCP promoted more osteogenesis than pure beta-TCP In vivo osteocalcin and type I collagen assay also revealed faster bone formation in rats with doped beta-TCP implant compared to rats with pure beta-TCP implant Low Ca2+ concentration in the urine of rats with doped beta-TCP implant confirmed slower degradation of MgO/SrO-doped beta-TCP than pure beta-TCP. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd All rights reserved

引用

页码：4167 / 4174

页数：8

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