Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatment

被引：46

作者：

Boxer, AL

Kramer, JH

Johnston, K

Goldman, J

Finley, R

Miller, BL

机构：

[1] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA

[2] Permanente Med Grp Inc, Dept Genet, San Francisco, CA USA

来源：

NEUROLOGY | 2005年 / 64卷 / 08期

关键词：

D O I：

10.1212/01.WNL.0000158476.74580.A8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

An elevated serum homocysteine level is a risk factor for the development of cognitive impairment. Reported is a late-onset case of hyperhomocystinemia due to a vitamin B-12 metabolic deficit ( cobalamin C) with cognitive impairment, primarily in frontal/executive function. After homocysteine-lowering therapy, the patient's functional and neuropsychological status improved in conjunction with a decrease in leukoariosis on his MRI scan. These findings suggest that homocysteine-related cognitive impairment may be partially reversible.

引用

页码：1431 / 1434

页数：4

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