PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis

被引：115

作者：

Krishna, G ^{[1
]}

Liu, KL ^{[1
]}

Shigemitsu, H ^{[1
]}

Gao, MX ^{[1
]}

Raffin, TA ^{[1
]}

Rosen, GD ^{[1
]}

机构：

[1] Stanford Univ, Med Ctr, Div Pulm & Crit Care Med, Stanford, CA 94305 USA

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2001年 / 158卷 / 03期

关键词：

D O I：

10.1016/S0002-9440(10)64046-1

中图分类号：

R36 [病理学];

学科分类号：

100104 [病理学与病理生理学];

摘要：

In this study we evaluate the antifibrotic properties of PG-490-88, a water-soluble derivative of triptolide. Triptolide is an oxygenated diterpene that is derived from a traditional Chinese herb that has potent immunosuppressive and antitumor activity. We used the intratracheal bleomycin mouse model and found that PG490-88 inhibits fibrosis in the bleomycin group when given the same day or 5 days after bleomycin. PG490-88 also markedly reduced the number of myofibroblasts in the bleomycin treatment group. An enzyme-linked immunosorbent assay of transforming growth factor (TGF)-beta in the bronchoalveolar lavage fluid showed a significant decrease in TGF-beta in the PG490-88-treated groups compared to the bleomycin-treated group. Additionally, triptolide blocked bleomycin-induced increase in TGF-beta mRNA in cultured normal human lung fibroblasts. The efficacy of PG490-88 when administered late after bleomycin installation suggests a potential role in the treatment of idiopathic pulmonary fibrosis.

引用

页码：997 / 1004

页数：8

共 28 条

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