Cooling and rewarming-induced IL-8 expression in human bronchial epithelial cells through p38 MAP kinase-dependent pathway

被引：66

作者：

Gon, Y ^{[1
]}

Hashimoto, S ^{[1
]}

Matsumoto, K ^{[1
]}

Nakayama, T ^{[1
]}

Takeshita, I ^{[1
]}

Horie, T ^{[1
]}

机构：

[1] Nihon Univ, Sch Med, Dept Internal Med 1, Tokyo 173, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 249卷 / 01期

关键词：

cold stress; p38 MAP kinase; bronchial epithelial cells;

D O I：

10.1006/bbrc.1998.9115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

p38 mitogen-activated protein kinase (MAP) kinase is activated by various stresses; however, little is known about cold stress which has been shown to cause various inflammatory diseases. In the present study, we examined the effect of cold stimulation on interleukin-8 (IL-8) expression and a role of p38 MAP kinase in IL-8expression in human bronchial epithelial cells (BEC) in order to clarify the mechanism in hypothermic temperature-induced inflammation. The results showed that cold stimulation induced tyrosine phosphorylation of p38 MAP kinase but not IL-8 expression. IL-8 expression in BEC was induced when the temperature of incubation changed from 1 degrees C to 37 degrees C (cooling and rewarming), The specific p38 MAP kinase inhibitor SE 203580 inhibited cooling and rewarming-induced IL-8 expression, indicating that cooling and rewarming-induced IL-8 expression in BEC was mediated through p38 MAP kinase-dependent pathway. (C) 1998 Academic Press.

引用

页码：156 / 160

页数：5

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