Epidemiology of Haemophilus influenzae serotype a, North American Arctic 2000-2005

被引：75

作者：

Bruce, Michael G. ^{[1
]}

Deeks, Shelley L. ^{[2
]}

Zulz, Tammy ^{[1
]}

Navarro, Christine ^{[2
]}

Palacios, Carolina ^{[3
]}

Case, Cheryl ^{[4
]}

Hemsley, Colleen ^{[5
]}

Hennessy, Tom ^{[1
]}

Corriveau, Andre ^{[4
]}

Larke, Bryce ^{[5
]}

Sobel, Isaac ^{[3
]}

Lovgren, Marguerite ^{[6
]}

DeByle, Carolynn ^{[1
]}

Tsang, Raymond ^{[7
]}

Parkinson, Alan J. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Anchorage, AK USA

[2] Publ Hlth Agcy Canada, Ottawa, ON, Canada

[3] Nunavut Dept Hlth, Iqaluit, NU, Canada

[4] Northwest Terr Dept Hlth & Social Serv, Yellowknife, NT, Canada

[5] Yukon Hlth & Social Serv, Whitehorse, YT, Canada

[6] Natl Ctr Streptococcus, Edmonton, AB, Canada

[7] Natl Microbiol Lab, Winnipeg, MB, Canada

来源：

EMERGING INFECTIOUS DISEASES | 2008年 / 14卷 / 01期

关键词：

D O I：

10.3201/eid1401.070822

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Before the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, rates of invasive H. influenzae disease among indigenous people of the North American Arctic were among the highest in the world. Routine vaccination reduced rates to low levels; however, serotype replacement with non-type b strains may result in a reemergence of invasive disease in children. We reviewed population-based data on invasive H. influenzae in Alaska and northern Canada from 2000-2005; 138 cases were reported. Among 88 typeable isolates, 42 (48%) were H. influenzae type a (Hia); 35 (83%) occurred in indigenous peoples. Among Hia patients, median age was 1.1 years; 62% were male; 1 adult died. Common clinical manifestations included meningitis, pneumonia, and septic arthritis. Overall annual incidence was 0.9 cases per 100,000 population. Incidence among indigenous children <2 years of age in Alaska and northern Canada was 21 and 102, respectively. Serotype a is now the most common H. influenzae serotype in the North American Arctic; the highest rates are among indigenous children.

引用

页码：48 / 55

页数：8

共 37 条

[1] Invasive serotype a Haemophilus influenzae infections with a virulence genotype resembling Haemophilus influenzae type b:: Emerging pathogen in the vaccine era? [J].