The total synthesis of (+)-pectinatone: An iterative alkylation approach based on the SAMP-hydrazone method

被引：40

作者：

Birkbeck, AA ^{[1
]}

Enders, D ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(98)01742-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The marine natural product (+)-pectinatone containing 'skip' 1,3-dimethyl stereocentres was synthesised via the iterative alkylation of propanal SAMP-hydrazone with beta-branched iodides. Factors affecting the selectivity of the alkylation reaction and the in situ formation of volatile beta-branched iodides are described. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7823 / 7826

页数：4

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