Spontaneous autoimmune gastritis in C3H/He mice -: A new mouse model for gastric autoimmunity

被引：17

作者：

Alderuccio, F ^{[1
]}

Toh, BH ^{[1
]}

机构：

[1] Monash Univ, Sch Med, Dept Pathol & Immunol, Melbourne, Vic 3181, Australia

来源：

AMERICAN JOURNAL OF PATHOLOGY | 1998年 / 153卷 / 04期

关键词：

D O I：

10.1016/S0002-9440(10)65676-3

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Autoimmune gastritis is the underlying pathological lesion of pernicious anemia in humans. The lesion is characterized by a chronic inflammatory infiltrate in the gastric mucosa with loss of parietal and zymogenic cells. It is associated with circulating autoantibodies to the gastric H/K-ATPase, the enzyme responsible for acidification of gastric juice. Experimental models of autoimmune gastritis have previously been produced in. mice after a variety of manipulations, including thymectomy. Here we report for the first time a spontaneous mouse model of autoimmune gastritis in C3H/He mice. The spontaneous gastritis is also accompanied by circulating autoantibodies to the gastric H/K-ATPase. The spontaneous mouse model should be useful for studies directed toward the immunopathogenesis and treatment of autoimmune gastritis.

引用

页码：1311 / 1318

页数：8

共 36 条

[1] Expression of the gastric H/K-ATPase alpha-subunit in the thymus may explain the dominant role of the beta-subunit in the pathogenesis of autoimmune gastritis [J].