Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction

被引：141

作者：

Jensen, Jens H. ^{[1
,2
]}

Falangola, Maria F. ^{[1
,3
]}

Hu, Caixia ^{[1
,3
]}

Tabesh, Ali ^{[1
]}

Rapalino, Otto ^{[4
]}

Lo, Calvin ^{[1
]}

Helpern, Joseph A. ^{[1
,2
,3
,5
]}

机构：

[1] NYU, Sch Med, Dept Radiol, Ctr Biomed Imaging, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Physiol & Neurosci, New York, NY 10016 USA

[3] Nathan S Kline Inst Psychiat Res, Ctr Adv Brain Imaging, Orangeburg, NY 10962 USA

[4] Massachusetts Gen Hosp, Dept Radiol, Neuroradiol Div, Boston, MA 02114 USA

[5] NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA

来源：

NMR IN BIOMEDICINE | 2011年 / 24卷 / 05期

基金：

美国国家卫生研究院;

关键词：

ischemia; stroke; diffusion; brain; kurtosis; DKI; DTI; MRI; GAUSSIAN WATER DIFFUSION; ENDOPLASMIC-RETICULUM; ISCHEMIC-STROKE; NEURONAL DEATH; RAT-BRAIN; MODEL; TISSUES;

D O I：

10.1002/nbm.1610

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

By application of the MRI method of diffusional kurtosis imaging, a substantially increased diffusional kurtosis was observed within the cerebral ischemic lesions of three stroke subjects, 13-26 h following the onset of symptoms. This increase is interpreted as probably reflecting a higher degree of diffusional heterogeneity in the lesions when compared with normal-appearing contralateral tissue. In addition, for two of the subjects with white matter infarcts, the increase had a strong fiber tract orientational dependence. It is proposed that this effect is consistent with a large drop in the intra-axonal diffusivity, possibly related to either axonal varicosities or alterations associated with the endoplasmic reticulum. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：452 / 457

页数：6

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