Enigmatic variations: Divergent modes of regulating eukaryotic DNA replication

被引：67

作者：

Kearsey, SE

Cotterill, S

机构：

[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

[2] Univ London St Georges Hosp, Sch Med, London SW16 ORE, England

来源：

MOLECULAR CELL | 2003年 / 12卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S1097-2765(03)00441-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteins involved in DNA replication are conserved from yeast to mammals, suggesting that the mechanism was established at an early stage of eukaryotic evolution. In spite of this common origin, recent findings have revealed surprising variations in how replication initiation is controlled, implying that a conserved mechanism has not necessarily resulted in regulatory conservation.

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收藏

页码：1067 / 1075

页数：9

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