Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure

被引：221

作者：

Carroll, Jenna C. ^{[1
,2
]}

Rosario, Emily R. ^{[1
]}

Kreimer, Sara ^{[1
]}

Villamagna, Angela ^{[1
]}

Gentzschein, Elisabet ^{[3
]}

Stanczyk, Frank Z. ^{[3
]}

Pike, Christian J. ^{[1
]}

机构：

[1] Univ So Calif, Davis Sch Gerontol, Los Angeles, CA 90089 USA

[2] Univ So Calif, Neurosci Grad Program, Los Angeles, CA 90089 USA

[3] Univ So Calif, Dept Obstet & Gynecol, Los Angeles, CA 90089 USA

来源：

BRAIN RESEARCH | 2010年 / 1366卷

关键词：

Alzheimer's disease; beta-amyloid; Estrogen; Testosterone; Neonatal; Sex difference; ESTROGEN REPLACEMENT THERAPY; TRANSGENIC MOUSE MODEL; PERSISTENT VAGINAL CORNIFICATION; GLOBAL COGNITIVE FUNCTION; HEALTH INITIATIVE MEMORY; ALZHEIMERS-DISEASE; MALE-RATS; PARTNER PREFERENCE; GENDER-DIFFERENCES; PRECURSOR-PROTEIN;

D O I：

10.1016/j.brainres.2010.10.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The risk of Alzheimer's disease (AD) is higher in women than in men, a sex difference that likely results from the effects of sex steroid hormones. To investigate this relationship, we first compared progression of beta-amyloid (A beta) pathology in male and female triple transgenic (3xTg-AD) mice. We found that female 3xTg-AD mice exhibit significantly greater A beta burden and larger behavioral deficits than age-matched males. Next, we evaluated how the organizational effects of sex steroid hormones during postnatal development may affect adult vulnerability to A beta pathology. We observed that male 3xTg-AD mice demasculinized during early development exhibit significantly increased A beta accumulation in adulthood. In contrast, female mice defeminized during early development exhibit a more male-like pattern of A beta pathology in adulthood. Taken together, these results demonstrate significant sex differences in pathology in 3xTg-AD mice and suggest that these differences may be mediated by organizational actions of sex steroid hormones during development. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：233 / 245

页数：13

共 111 条

[1]

Akhmadeev A. V., 2005, Ontogenez, V36, P64

[2]

Correlation between testosterone, gonadotropins and prolactin and severity of negative symptoms in male patients with chronic schizophrenia [J].

Akhondzadeh, Shahin ;

Rezaei, Farzin ;

Larijani, Bagher ;

Nejatisafa, Ali-Akbar ;

Kashani, Ladan ;

Abbasi, Seyed Hesameddin .

SCHIZOPHRENIA RESEARCH, 2006, 84 (2-3) :405-410

[3]

Neuroprotective effects of female gonadal steroids in reproductively senescent female rats [J].

Alkayed, NJ ;

Murphy, SJ ;

Traystman, RJ ;

Hurn, PD .

STROKE, 2000, 31 (01) :161-167

[4]

Flutamide induces ultrastructural changes in spermatids and the ectoplasmic specialization between the Sertoli cell and spermatids in mouse testes [J].

Anahara, R ;

Toyama, Y ;

Mori, C .

REPRODUCTIVE TOXICOLOGY, 2004, 18 (04) :589-596

[5]

Gender differences in the incidence of AD and vascular dementia - The EURODEM Studies [J].

Andersen, K ;

Launer, LJ ;

Dewey, ME ;

Letenneur, L ;

Ott, A ;

Copeland, JRM ;

Dartigues, JF ;

Kragh-Sorensen, P ;

Baldereschi, M ;

Brayne, C ;

Lobo, A ;

Martinez-Lage, JM ;

Stijnen, T ;

Hofman, A .

NEUROLOGY, 1999, 53 (09) :1992-1997

[6]

Effects of neonatal and prepubertal hormonal manipulations upon estrogen neuroprotection of the nigrostriatal dopaminergic system within female and male mice [J].

Anderson, LI ;

Leipheimer, RE ;

Dluzen, DE .

NEUROSCIENCE, 2005, 130 (02) :369-382

[7]

Digit length pattern in schizophrenia suggests disturbed prenatal hemispheric lateralization [J].

Arató, M ;

Frecska, E ;

Beck, C ;

An, M ;

Kiss, H .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2004, 28 (01) :191-194

[8]

PREVALENCE OF DEMENTIA AND PROBABLE SENILE DEMENTIA OF THE ALZHEIMER TYPE IN THE FRAMINGHAM-STUDY [J].

BACHMAN, DL ;

WOLF, PA ;

LINN, R ;

KNOEFEL, JE ;

COBB, J ;

BELANGER, A ;

DAGOSTINO, RB ;

WHITE, LR .

NEUROLOGY, 1992, 42 (01) :115-119

[9]

Role for estradiol in female-typical brain and behavioral sexual differentiation [J].

Bakker, Julie ;

Baum, Michael J. .

FRONTIERS IN NEUROENDOCRINOLOGY, 2008, 29 (01) :1-16

[10]

Sex differences in the clinical manifestations of Alzheimer disease pathology [J].

Barnes, LL ;

Wilson, RS ;

Bienias, JL ;

Schneider, JA ;

Evans, DA ;

Bennett, DA .

ARCHIVES OF GENERAL PSYCHIATRY, 2005, 62 (06) :685-691

← 1 2 3 4 5 6 7 8 9 10 →