COX-2 inhibitors for the prevention of breast cancer

被引:49
作者
Howe, LR
Dannenberg, AJ
机构
[1] Rockefeller Univ, Strang Canc Res Lab, New York, NY 10021 USA
[2] Cornell Univ, Weil Med Coll, Dept Cell & Dev Biol, New York, NY USA
[3] New York Presbyterian Hosp, Dept Med, New York, NY USA
关键词
COX-2; HER2/neu; chemoprevention; prognostic indicator; prostaglandin; angiogenesis; breast cancer;
D O I
10.1023/A:1025731204719
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The inducible prostaglandin synthase cyclooxygenase-2 (COX-2) is normally expressed predominantly in kidney and brain, and also has important roles in reproduction and inflammation. COX-2 misexpression has been observed in numerous human cancers, including the majority of colorectal cancers. Recently, COX-2 overexpression has been described in human breast cancer. COX-2 is present in about 40% of invasive breast carcinomas, particularly those that overexpress HER2/neu, and COX-2 expression correlates with poor patient prognosis. Manipulation of Cox-2 gene dosage by using transgenic overexpression and knockout approaches has revealed an important role for Cox-2 in tumorigenesis. Furthermore, translational experiments using rodent breast cancer models suggest COX-2 inhibition to be an effective strategy for both prevention and treatment of experimental breast cancers. Since COX-2 can contribute to multiple facets of tumorigenesis, including angiogenesis, several mechanisms are likely to underlie the anticancer action of COX inhibitors. Thus, selective COX-2 inhibitors offer considerable promise for the prevention and treatment of human breast cancer.
引用
收藏
页码:31 / 43
页数:13
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