Large changes in regulome size herald the main prokaryotic lineages

被引：17

作者：

Cordero, Otto X. ^{[1
]}

Hogeweg, P. ^{[1
]}

机构：

[1] Univ Utrecht, Dept Theoret Biol & Bioinformat, NL-3584 CH Utrecht, Netherlands

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 10期

关键词：

D O I：

10.1016/j.tig.2007.07.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Using a large-scale reconstruction of ancestral gene content, we show that radical changes in regulome size occur at the origins of major prokaryotic lineages. Subsequently, the duplication and deletion of regulators slows down in most lineages, except proteobacteria, significantly reducing the scaling of regulators and keeping their average proportion lineage-specific. Our results also suggest that major transitions in prokaryote evolution are related to changes in regulatory capacity rather than proteome innovations.

引用

页码：488 / 493

页数：6

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