Effects of diabetes on tissue content and evoked release of calcitonin gene-related peptide-like immunoreactivity from rat sensory nerves

被引:23
作者
Calcutt, NA [1 ]
Chen, P
Hua, XY
机构
[1] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Anesthesiol, La Jolla, CA 92093 USA
关键词
neuropathy; calcitonin gene-related peptide; trachea; neuropeptides; vagus nerve; capsaicin; diabetes;
D O I
10.1016/S0304-3940(98)00692-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We measured the evoked release of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) from sensory nerve terminals in tracheas from control and diabetic rats using an in vitro perfusion system and also the CGRP-LI content of the vagus nerve and trachea. Diabetes caused a 29% (P < 0.05) reduction in CGRP-LI content of the vagus nerve and a decrease in CGRP-LI release from nerve endings in the trachea evoked by either capsaicin (30% decrease, P < 0.05) or electrical field stimulation (50% decrease: P < 0.05). In contrast, there was a 50% increase in the CGRP-LI content of the unstimulated trachea. Thus, diabetes induces an impairment in neuropeptide release from peripheral terminals of sensory nerves that corresponds to decreased levels in the supplying nerve but is not reflected in tissue measurements that incorporate nerve terminals. Impaired neuropeptide release may contribute to peripheral and central sensory dysfunction in diabetic rats. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:129 / 132
页数:4
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