Determination of IGHV gene mutational status in chronic lymphocytic leukemia: bioinformatics advances meet clinical needs

被引：6

作者：

Davi, F. ^{[1
,2
]}

Rosenquist, R. ^{[3
,4
]}

Ghia, P. ^{[5
]}

Belessi, C. ^{[6
]}

Stamatopoulos, K. ^{[7
,8
]}

机构：

[1] Univ Paris 06, Hop La Pitie Salpetriere, Paris, France

[2] Hop La Pitie Salpetriere, Hematol Lab, Paris, France

[3] Uppsala Univ, Dept Genet & Pathol, Uppsala, Sweden

[4] Univ Vita Salute San raffaele, Dept Oncol, Milan, Italy

[5] Ist Sci San Raffaele, Milan, Italy

[6] Nikea Gen Hosp, Dept Hematol, Athens, Greece

[7] G Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece

[8] G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece

来源：

LEUKEMIA | 2008年 / 22卷 / 01期

关键词：

D O I：

10.1038/sj.leu.2404969

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

引用

页码：212 / 214

页数：3

共 6 条

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[2]

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[3]

Analysis of VH gene sequences using two web-based immunogenetics resources gives different results, but the affinity maturation status of chronic lymphocytic leukaemia clones as assessed from either of the resulting data sets has no prognostic significance [J].

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[4]

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[5]

Multivariate analysis of prognostic factors in CLL:: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors [J].

Oscier, DG ;

Gardiner, AC ;

Mould, SJ ;

Glide, S ;

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[6]

Pekova Sona, 2006, Haematologica, V91, pELT01

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