Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

被引：115

作者：

Babur, Ozgun ^{[1
]}

Gonen, Mithat ^{[2
]}

Aksoy, Bulent Arman ^{[1
,3
]}

Schultz, Nikolaus ^{[1
]}

Ciriello, Giovanni ^{[1
]}

Sander, Chris ^{[1
]}

Demir, Emek ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Computat Biol Ctr, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA

[3] Tri Inst Training Program Computat Biol & Med, New York, NY 10065 USA

来源：

GENOME BIOLOGY | 2015年 / 16卷

基金：

美国国家卫生研究院;

关键词：

MUTATED DRIVER PATHWAYS; RHO-GTPASES; MUTATIONS; PATTERNS; SEARCH;

D O I：

10.1186/s13059-015-0612-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We present a novel method for the identification of sets of mutually exclusive gene alterations in a given set of genomic profiles. We scan the groups of genes with a common downstream effect on the signaling network, using a mutual exclusivity criterion that ensures that each gene in the group significantly contributes to the mutual exclusivity pattern. We test the method on all available TCGA cancer genomics datasets, and detect multiple previously unreported alterations that show significant mutual exclusivity and are likely to be driver events.

引用

页数：10

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