The role of bone morphogenetic proteins in endochondral bone formation

被引：131

作者：

Tsumaki, N ^{[1
]}

Yoshikawa, H ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Orthopaed Surg, Suita, Osaka 5650871, Japan

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2005年 / 16卷 / 03期

关键词：

Smads; smurfs; cartilage; transgenic mice; knockout mice;

D O I：

10.1016/j.cytogfr.2005.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Bone morphogenetic proteins (BMPs) were originally identified as proteins capable of inducing endochondral bone formation when implanted at extraskeletal sites. BMPs have diverse biological activities during early embryogenesis and various aspects of organogenesis. BMPs bind to BMP receptors on the cell surface, and these signals are transduced intracellularly by Smad proteins. BMP signal pathways can be inhibited by both extra- and intracellular mechanisms. As for skeletal development, genetic studies suggest that BMPs are skeletal mesoderm inducers. Recent studies of tissue-specific activation and inactivation of BMP signals have revealed that BMP signals control proliferation and differentiation of chondrocytes, differentiation of osteoblasts and bone quality. These findings may contribute not only to understanding of bone biology and pathology, but also to improvement of the clinical efficacy of BMPs. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：279 / 285

页数：7

共 80 条

[1]

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: Antagonism by noggin [J].