Human herpesvirus 6 latently infects early bone marrow progenitors in vivo

被引：96

作者：

Luppi, M

Barozzi, P

Morris, C

Maiorana, A

Garber, R

Bonacorsi, G

Donelli, A

Marasca, R

Tabilio, A

Torelli, G ^{[1
]}

机构：

[1] Univ Modena, Dept Med Sci, Sect Hematol, I-41100 Modena, Italy

[2] Univ Modena, Dept Pathol, I-41100 Modena, Italy

[3] Univ Perugia, Dept Clin & Expt Med, Clin Hematol & Immunol, I-06100 Perugia, Italy

[4] Christchurch Sch Med, Dept Pathol, Cytogenet & Mol Oncol Unit, Christchurch, New Zealand

[5] PathoGenesis Corp, Seattle, WA USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 01期

关键词：

D O I：

10.1128/JVI.73.1.754-759.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells in patients with latent HHV-6 infection. Having used a variety of cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report the first evidence that HHV-6 latently infects early bone marrow progenitor cells and that HHV-6 may be transmitted longitudinally to cells which differentiate along the committed pathways.

引用

页码：754 / 759

页数：6

共 24 条

[1] UTILIZATION OF HUMAN HEMATOPOIETIC-CELL LINES FOR THE PROPAGATION AND CHARACTERIZATION OF HBLV (HUMAN HERPESVIRUS-6)
ABLASHI, DV
LUSSO, P
HUNG, CL
SALAHUDDIN, SZ
JOSEPHS, SF
LLANA, T
KRAMARSKY, B
BIBERFELD, P
MARKHAM, PD
GALLO, RC
[J]. INTERNATIONAL JOURNAL OF CANCER, 1988, 42 (05) : 787 - 791
[2] BEAULIEU AD, 1995, BLOOD, V86, P2789
[3] PLAQUE-ASSOCIATED EXPRESSION OF HUMAN HERPESVIRUS-6 IN MULTIPLE-SCLEROSIS
CHALLONER, PB
SMITH, KT
PARKER, JD
MACLEOD, DL
COULTER, SN
ROSE, TM
SCHULTZ, ER
BENNETT, JL
GARBER, RL
CHANG, M
SCHAD, PA
SEWART, PM
NOWINSKI, RC
BROWN, JP
BURMER, GC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) : 7440 - 7444
[4] IMMUNOSUPPRESSIVE EFFECT OF HUMAN HERPESVIRUS-6 ON T-CELL FUNCTIONS - SUPPRESSION OF INTERLEUKIN-2 SYNTHESIS AND CELL-PROLIFERATION
FLAMAND, L
GOSSELIN, J
STEFANESCU, I
ABLASHI, D
MENEZES, J
[J]. BLOOD, 1995, 85 (05) : 1263 - 1271
[5] Concurrent human herpesvirus-6 infection renders two human hematopoietic progenitor (TF-1 and KG-1) cell lines susceptible to human immunodeficiency virus type-1
Furlini, G
Vignoli, M
Ramazzotti, E
Re, MC
Visani, G
LaPlaca, M
[J]. BLOOD, 1996, 87 (11) : 4737 - 4745
[6] GENOMIC ANALYSIS OF THE HUMAN B-LYMPHOTROPIC VIRUS (HBLV)
JOSEPHS, SF
ZAKISALAHUDDIN, S
ABLASHI, DV
SCHACHTER, F
WONGSTAAL, F
GALLO, RC
[J]. SCIENCE, 1986, 234 (4776) : 601 - 603
[7] A REPEAT SEQUENCE, GGGTTA, IS SHARED BY DNA OF HUMAN HERPESVIRUS-6 AND MAREKS-DISEASE VIRUS
KISHI, M
HARADA, H
TAKAHASHI, M
TANAKA, A
HAYASHI, M
NONOYAMA, M
JOSEPHS, SF
BUCHBINDER, A
SCHACHTER, F
ABLASHI, DV
WONGSTAAL, F
SALAHUDDIN, SZ
GALLO, RC
[J]. JOURNAL OF VIROLOGY, 1988, 62 (12) : 4824 - 4827
[8] 3 CASES OF HUMAN HERPESVIRUS-6 LATENT INFECTION - INTEGRATION OF VIRAL GENOME IN PERIPHERAL-BLOOD MONONUCLEAR CELL-DNA
LUPPI, M
MARASCA, R
BAROZZI, P
FERRARI, S
CECCHERININELLI, L
BATONI, G
MERELLI, E
TORELLI, G
[J]. JOURNAL OF MEDICAL VIROLOGY, 1993, 40 (01) : 44 - 52
[9] INFECTION OF NATURAL-KILLER-CELLS BY HUMAN HERPESVIRUS-6
LUSSO, P
MALNATI, MS
GARZINODEMO, A
CROWLEY, RW
LONG, EO
GALLO, RC
[J]. NATURE, 1993, 362 (6419) : 458 - 462
[10] INVITRO CELLULAR TROPISM OF HUMAN LYMPHOTROPIC-B VIRUS (HUMAN HERPESVIRUS-6)
LUSSO, P
MARKHAM, PD
TSCHACHLER, E
VERONESE, FD
SALAHUDDIN, SZ
ABLASHI, DV
PAHWA, S
KROHN, K
GALLO, RC
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (05) : 1659 - 1670

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