Identification of a long variant of mRNA encoding the NR3 subunit of the NMDA receptor: its regional distribution and developmental expression in the rat brain

被引：79

作者：

Sun, LX

Margolis, FL

Shipley, MT

Lidow, MS

机构：

[1] Univ Maryland, Dept Oral & Craniofacial Biol Sci, Baltimore, MD 21201 USA

[2] Univ Maryland, Dept Anat & Neurobiol, Baltimore, MD 21201 USA

[3] Univ Maryland, Program Neurosci, Baltimore, MD 21201 USA

来源：

FEBS LETTERS | 1998年 / 441卷 / 03期

基金：

美国国家卫生研究院;

关键词：

NMDA receptor; NR3; subunit; variant; cloning; phosphorylation; distribution; development;

D O I：

10.1016/S0014-5793(98)01590-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A longer variant of rat mRNA encoding the NR3 subunit of the NMDA receptor has been identified. It contains a 60-bp insertion at the nucleotide position 3007 in the intracellular domain of the C-terminal of the previously cloned variant. Therefore, the NR3 mRNA exists in at least two variants - with the insert (NR3-long; NR3-1) and without the insert (NR3-short; NR3-s), The NR3-1 variant is expressed throughout the adult rat brain. Moreover, this variant predominates in the occipital and entorhinal cortices, thalamus and cerebellum. Analysis of NR3-1 development indicates that it is regulated in a region-specific manner. (C) 1998 Federation of European Biochemical Societies.

引用

页码：392 / 396

页数：5

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