ACaMKII autophosphorylation contributes to rapid learning but is not necessary for memory

被引：103

作者：

Irvine, EE ^{[1
]}

Vernon, J ^{[1
]}

Giese, KP ^{[1
]}

机构：

[1] UCL, Wolfson Inst Biomed Res, London WC1E 6BT, England

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nn1431

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autophosphorylation of a calcium - calmodulin-dependent kinase II (alpha CaMKII) has been proposed to be the key event in memory storage. We tested this hypothesis with autophosphorylation-deficient mutant mice in hippocampus- and amygdala-dependent learning and memory tasks and found that the autophosphorylation of aCaMKII was required for rapid learning but was not essential for memory. We conclude that aCaMKII autophosphorylation contributes to single-trial learning but is dispensable for memory.

引用

页码：411 / 412

页数：2

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