Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors

被引：14

作者：

Moriyama, H

Tsukida, T

Inoue, Y

Kondo, H

Yoshino, K

Nishimura, SI

机构：

[1] Japan Bioind Assoc, Hokkaido Collaborat Ctr, Sapporo, Hokkaido 0010021, Japan

[2] Nippon Organon KK, R&D Labs, Miyakojima Ku, Osaka 5340016, Japan

[3] Hokkaido Univ, Grad Sch Sci, Div Biol Sci, Kita Ku, Sapporo, Hokkaido 0010021, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(03)00531-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In order to verify whether azasugar would be a useful scaffold for inhibitory activity against metalloproteinases, we synthesized some azasugar-based compounds. As a result, it is clarified that azasugar moiety could function as successful inhibitor of matrix metalloproteinase-1, -3 and -9 and TACE. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：2741 / 2744

页数：4

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