Synthesis and SAR of diiodotyrosine-derived glycine-site N-methyl-D-aspartate receptor ligands

被引:6
作者
Curtis, NR
Kulagowski, JJ
Leeson, PD
Mawer, IM
Ridgill, MP
Rowley, M
Grimwood, S
Marshall, GR
机构
[1] Merck Sharp and Dohme Res. Labs., Neuroscience Research Centre, Harlow, Essex CM20 2QR, Terlings Park, Eastwick Road
关键词
D O I
10.1016/0960-894X(96)00187-4
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of analogues of the novel diiodotyrosine derived NMDA glycine-site ligand (R)-4 was prepared in which the aryl substitution, chain length and amino acid groups were varied. The key structural features for binding are the alpha-amino acid function, having the (R) absolute stereochemistry, the 3,5-diiodo substituted aromatic ring and a lipophilic group attached at the phenolic oxygen of the tyrosine moiety. (C) 1996 Elsevier Science Ltd
引用
收藏
页码:1145 / 1150
页数:6
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