In vitro effect of amikacin, imipenem, cefodizime, IFNα-2a alone and combinations of antibiotics with IFNα-2a on polymorphonuclear leukocyte function in chronic hepatitis patients

被引：7

作者：

Adalati, R

Gürer, ÜS

Çevikbas, A ^{[1
]}

Johansson, C

机构：

[1] Univ Marmara, Fac Pharm, Dept Pharmaceut Microbiol, TR-81010 Istanbul, Turkey

[2] Numune State Hosp, Dept Microbiol, Istanbul, Turkey

[3] Univ Marmara, Fac Med, Dept Microbiol, TR-81010 Istanbul, Turkey

来源：

CHEMOTHERAPY | 2001年 / 47卷 / 04期

关键词：

amikacin; imipenem; cefodizime; IFN alpha-2a; polymorphonuclear leukocyte functions; chronic hepatitis B patients;

D O I：

10.1159/000048532

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The in vitro effect of amikacin (8 mug/ml), imipenem (30 mug/ml), cefodizime (10 mug/ml), interferon alpha -2a (IFN alpha -2a) (10 IU/ml) and antibiotic combinations with IFNa-2a on polymorphonuclear leukocyte (PMN) functions (phagocytosis and intracellular killing of Candida albicans blastospores) was investigated in chronic hepatitis B patients. Phagocytosis and candidacidal activity was not affected after pretreatment of PMNs with amikacin and imipenem (p > 0.05). Phagocytic activity was enhanced after pretreatment of PMNs with cefodizime and IFN alpha -2a compared with that of control PMNs (p < 0.05), but candidacidal activity was not affected by the same drugs (p > 0.05). Phagocytic and intracellular activity of PMNs were not affected by combinations of IFN alpha -2a and antibiotics (p > 0.05). Copyright (C) 2001 S. Ka rger AG, Baser.

引用

页码：261 / 265

页数：5

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