An artificially designed pore-forming protein with anti-tumor effects

被引:20
作者
Ellerby, HM [1 ]
Lee, S
Ellerby, LM
Chen, S
Kiyota, T
del Rio, G
Sugihara, G
Sun, Y
Bredesen, DE
Arap, W
Pasqualini, R
机构
[1] Buck Inst, Program Canc & Aging, Novato, CA 94945 USA
[2] Fukuoka Univ, Fac Sci, Dept Chem, Jonan Ku, Fukuoka 81480, Japan
[3] Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA
关键词
D O I
10.1074/jbc.M300474200
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Protein engineering is an emerging area that has expanded our understanding of protein folding and laid the groundwork for the creation of unprecedented structures with unique functions. We previously designed the first native-like pore-forming protein, small globular protein (SGP). We show here that this artificially engineered protein has membrane-disrupting properties and anti-tumor activity in several cancer animal models. We propose and validate a mechanism for the selectivity of SGP toward cell membranes in tumors. SGP is the prototype for a new class of artificial proteins designed for therapeutic applications.
引用
收藏
页码:35311 / 35316
页数:6
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