Adaptive immunity in the host-microbiota dialog

被引:74
作者
Feng, T. [1 ]
Elson, C. O. [1 ]
机构
[1] Univ Alabama Birmingham, Dept Med, Div Gastroenterol & Hepatol, Birmingham, AL 35294 USA
关键词
REGULATORY T-CELLS; SEGMENTED FILAMENTOUS BACTERIA; DENDRITIC CELLS; CUTTING EDGE; SPONTANEOUS PROLIFERATION; TH17; CELLS; KEY ROLE; IGA; MUCOSAL; INFLAMMATION;
D O I
10.1038/mi.2010.60
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The intestinal tract represents the largest mucosal surface and is a major site of multifaceted interactions between the host mucosal immune system and components of the intestinal microbiota. Host immune responses to the commensal microbiota are tightly controlled and, meanwhile, the microbiota actively shapes intestinal immune responses to itself. Appreciation of these interactions during health and disease may direct therapeutic approaches to a broad range of autoimmune and inflammatory disorders in humans. In this review, we will discuss findings on how the intestinal immune system, especially adaptive immune cells, helps accommodate the large number of resident bacteria, and in turn how the microbiota shapes intestinal immune responses to achieve mutualism.
引用
收藏
页码:15 / 21
页数:7
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