3D Reconstruction of Histological Sections: Application to Mammary Gland Tissue

被引：501

作者：

Arganda-Carreras, Ignacio ^{[1
]}

Fernandez-Gonzalez, Rodrigo ^{[2
]}

Munoz-Barrutia, Arrate ^{[3
]}

Ortiz-De-Solorzano, Carlos ^{[3
]}

机构：

[1] Univ Autonoma Madrid, CSIC, CNB, Biocomp Unit, E-28049 Madrid, Spain

[2] Sloan Kettering Inst, Dev Biol Program, New York, NY USA

[3] Ctr Appl Med Res CIMA, Canc Imaging Lab, Pamplona, Spain

来源：

MICROSCOPY RESEARCH AND TECHNIQUE | 2010年 / 73卷 / 11期

关键词：

computer-assisted microscopy; assisted histopathology; image registration; 3-DIMENSIONAL RECONSTRUCTION; SUSCEPTIBILITY; PROLIFERATION; DEFORMATIONS; SYSTEM;

D O I：

10.1002/jemt.20829

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100123 [人体微生态学]; 100210 [外科学];

摘要：

In this article, we present a novel method for the automatic 3D reconstruction of thick tissue blocks from 2D histological sections. The algorithm completes a high-content (multi-scale, multifeature) imaging system for simultaneous morphological and molecular analysis of thick tissue samples. This computer-based system integrates image acquisition, annotation, registration, and three-dimensional reconstruction. We present an experimental validation of this tool using both synthetic and real data. In particular, we present the 3D reconstruction of an entire mouse mammary gland and demonstrate the integration of high-resolution molecular data. Microsc. Res. Tech. 73: 1019-1029, 2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：1019 / 1029

页数：11

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