Haliclonacyclamines A and B, cytotoxic alkaloids from the tropical marine sponge Haliclona sp.

被引：77

作者：

Charan, RD

Garson, MJ

Brereton, IM

Willis, AC

Hooper, JNA

机构：

[1] UNIV QUEENSLAND,DEPT CHEM,BRISBANE,QLD 4072,AUSTRALIA

[2] UNIV QUEENSLAND,CTR MAGNET RESONNACE,BRISBANE,QLD 4072,AUSTRALIA

[3] AUSTRALIAN NATL UNIV,RES SCH CHEM,CANBERRA,ACT 0200,AUSTRALIA

[4] QUEENSLAND MUSEUM,BRISBANE,QLD 4141,AUSTRALIA

来源：

TETRAHEDRON | 1996年 / 52卷 / 27期

关键词：

D O I：

10.1016/0040-4020(96)00436-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structures of haliclonacyclamines A (1) and B (2), and their methiodide salts (3) and (4), were investigated by 1D- and 2D-NMR experiments, notably DQFCOSY, HMBC, HMQC-HOHAHA, and HOHAHA. The relative stereochemistry and position of alkene substituents were determined by single crystal x-ray study at low temperature. The parent haliclonacyclamines show pronounced cytotoxic, antibacterial and antifungal activity. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：9111 / 9120

页数：10

共 31 条

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