Cross-clade cytotoxic T cell response to human immunodeficiency virus type 1 proteins among HLA disparate North Americans and Thais

被引：57

作者：

Lynch, JA

deSouza, R

Robb, MD

Markowitz, L

Nitayaphan, S

Sapan, CV

Mann, DL

Birx, DL

Cox, JH

机构：

[1] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20850 USA

[2] Walter Reed Army Med Ctr, Dept Pediat, Div Infect Dis, Washington, DC 20307 USA

[3] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Retrovirol, Washington, DC 20307 USA

[4] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand

[5] NABI Inc, Boca Raton, FL USA

[6] Univ Maryland, Div Immunogenet, Baltimore, MD 21201 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1998年 / 178卷 / 04期

关键词：

D O I：

10.1086/515652

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A globally effective vaccine will need to elicit cytotoxic T lymphocytes (CTL) capable of recognizing diverse human immunodeficiency virus type I (HIV-1) clades. Study of the cellular immune responses of HIV-1-infected persons may allow predictions to be made regarding useful vaccine antigen components. The frequency and magnitude of CTL responses to clade E and B Gag, Pol- RT, Env, and Nef proteins were compared in 12 HLA-characterized, clade E-infected Thais and in 10 clade B-infected North Americans using vaccinia recombinant constructs for protein expression. While responses were detected against all proteins, they were most frequent and cross-reactive to Gag in both groups. Pol-RT was recognized less frequently in Thais than North Americans. Cross-clade protein recognition was common but not uniformly present among these HLA-disparate individuals. Population-specific CTL data are needed to adequately prepare for vaccine trials outside of North America and Europe.

引用

页码：1040 / 1046

页数：7

共 43 条

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