RANTES mRNA expression in skin and colon of patients with atopic dermatitis

被引：34

作者：

Yamada, H

Izutani, R

Chihara, J

Yudate, T

Matsukura, M

Tezuka, T

机构：

[1] KINKI UNIV,DEPT SURG,SAYAMA,OSAKA 590,JAPAN

[2] AKITA UNIV,SCH MED,DEPT CLIN LAB & MED,AKITA 010,JAPAN

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1996年 / 111卷

关键词：

RANTES; cytokine; atopy; dermatitis;

D O I：

10.1159/000237408

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The expression of RANTES mRNA in dermal and colonic tissue was examined in patients with atopic dermatitis by the reverse transcription polymerase chain reaction method. RANTES mRNA was detected in the colon in 8 of 10 patients and in 1 of 5 control patients. It was present in rashes in 9 of 10 patients and at non-eruptive sites in 5 of 7 patients. These findings suggest that RANTES is involved in eosinophil infiltration and T cell infiltration in atopic dermatitis.

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收藏

页码：19 / 21

页数：3

相关论文

共 11 条

[1]

ALAM R, 1993, J IMMUNOL, V150, P3442

[2] SKIN EOSINOPHILIA IN PATIENTS WITH ALLERGIC AND NONALLERGIC ASTHMA AND ATOPIC-DERMATITIS [J].

BRUIJNZEELKOOMEN, C ;

STORZ, E ;

MENZ, G ;

BRUIJNZEEL, P .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1992, 89 (01) :52-59

[3] CYTOKINE RANTES RELEASED BY THROMBIN-STIMULATED PLATELETS IS A POTENT ATTRACTANT FOR HUMAN EOSINOPHILS [J].

KAMEYOSHI, Y ;

DORSCHNER, A ;

MALLET, AI ;

CHRISTOPHERS, E ;

SCHRODER, JM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (02) :587-592

[4] THE CHEMOKINE RANTES IS MORE THAN A CHEMOATTRACTANT - CHARACTERIZATION OF ITS EFFECT ON HUMAN EOSINOPHIL OXIDATIVE-METABOLISM AND MORPHOLOGY IN COMPARISON WITH IL-5 AND GM-CSF [J].

KAPP, A ;

ZECKKAPP, G ;

CZECH, W ;

SCHOPF, E .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 102 (06) :906-914

[5]

MACLEAN A, 1994, LANCET, V343, P189

[6] MECHANISMS OF EOSINOPHIL RECRUITMENT [J].

RESNICK, MB ;

WELLER, PF .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1993, 8 (04) :349-355

[7] SELECTIVE ATTRACTION OF MONOCYTES AND LYMPHOCYTES-T OF THE MEMORY PHENOTYPE BY CYTOKINE RANTES [J].

SCHALL, TJ ;

BACON, K ;

TOY, KJ ;

GOEDDEL, DV .

NATURE, 1990, 347 (6294) :669-671

[8] CYTOKINE NETWORKS IN THE SKIN [J].

SCHRODER, JM .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 105 (01) :S20-S24

[9] RANTES ROLE IN RHEUMATOID-ARTHRITIS [J].

SNOWDEN, N ;

HAJEER, A ;

THOMSON, W ;

OLLIER, B .

LANCET, 1994, 343 (8896) :547-548

[10] ATOPIC-DERMATITIS - CORRELATION OF PERIPHERAL-BLOOD T-CELL ACTIVATION, EOSINOPHILIA AND SERUM FACTORS WITH CLINICAL SEVERITY [J].

WALKER, C ;

KAGI, MK ;

INGOLD, P ;

BRAUN, P ;

BLASER, K ;

BRUIJNZEELKOOMEN, CAFM ;

WUTHRICH, B .

CLINICAL AND EXPERIMENTAL ALLERGY, 1993, 23 (02) :145-153