Correlation between cystatin C- and renal scan-determined glomerular filtration rate in children with spina bifida

被引:27
作者
Morgan, Catherine [1 ]
Senthilselvan, Ambikaipakan [2 ]
Bamforth, Fiona [3 ]
Hoskinson, Michael [4 ]
Gowrishankar, Manjula [1 ]
机构
[1] Univ Alberta Hosp, Dept Pediat, Walter Mac Kenzie Hlth Sci Ctr 2B2-42, Edmonton, AB T6G 2R7, Canada
[2] Univ Alberta, Sch Publ Hlth, Dept Publ Sci, Edmonton, AB T6G 2G3, Canada
[3] Univ Alberta Hosp, Clin Lab Med & Pathol Serv, Walter Mac Kenzie Hlth Sci Ctr 4B4 02, Edmonton, AB T6G 2R7, Canada
[4] Univ Alberta Hosp, Dept Radiol & Daignost Imaging, Walter Mac Kenzie Hlth Sci Ctr 4A3 22, Edmonton, AB T6G 2R7, Canada
关键词
renal function; prediction equations; biomarkers; monitoring; spinal dysraphism;
D O I
10.1007/s00467-007-0613-0
中图分类号
R72 [儿科学];
学科分类号
100202 [儿科学];
摘要
We report on the relationships between serum cystatin C level, glomerular filtration rate (GFR) estimated from a cystatin C-based prediction equation (that of Filler and Lepage), GFR calculated by the Schwartz formula and technetium 99m-diethylene triamine penta-acetic acid (Tc-99-DTPA)-determined GFR in 28 children with spina bifida. All children underwent measurement of height, weight, serum cystatin C level, and serum creatinine level at the time of their renal scan. The relationship between variables was assessed by Pearson correlation. Pearson correlation for the relationship between Tc-99-DTPA GFR and GFR calculated by the cystatin C-based equation was significant and higher than that of the relationship between Tc-99-DTPA GFR and GFR calculated by the Schwartz equation, which was not statistically significant. The correlation for Filler GFR was 0.42 (P=0.03) and for Schwartz GFR was 0.21 (P=0.28). Although we use renal scan determination of GFR as the best measure, and a creatinine-based formula as the most practical measure, perhaps a formula such as that published by Filler and Lepage, which is not dependent on anthropometric data, might be a more useful (and accurate) tool for establishing GFR in children with spina bifida.
引用
收藏
页码:329 / 332
页数:4
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