Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

被引：479

作者：

He, Yan ^{[1
]}

Yue, Yuan ^{[1
]}

Zheng, Xi ^{[1
,2
]}

Zhang, Kun ^{[1
]}

Chen, Shaohua ^{[3
,4
]}

Du, Zhiyun ^{[1
]}

机构：

[1] Guandong Univ Technol, Inst Nat Med & Green Chem, Sch Chem Engn & Light Ind, Guangzhou Higher Educ Mega Ctr, Guangzhou 510006, Guangdong, Peoples R China

[2] Rutgers State Univ, Dept Biol Chem, Ernest Mario Sch Pharm, Susan Lehman Cullman Lab Canc Res, Piscataway, NJ 08854 USA

[3] Guangdong Gen Hosp, Dept Otorhinolaryngol, Guangzhou 510030, Guangdong, Peoples R China

[4] Guangdong Acad Med Sci, Guangzhou 510030, Guangdong, Peoples R China

来源：

MOLECULES | 2015年 / 20卷 / 05期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

curcumin; antioxidant; inflammation; chronic diseases; MICROVASCULAR ENDOTHELIAL-CELLS; SOLID LIPID NANOPARTICLES; INDUCED OXIDATIVE STRESS; ACID-INDUCED COLITIS; I CLINICAL-TRIAL; NF-KAPPA-B; CHRONIC-PANCREATITIS; NATURAL-PRODUCTS; GENE-EXPRESSION; PROINFLAMMATORY CYTOKINES;

D O I：

10.3390/molecules20059183

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

It is extensively verified that continued oxidative stress and oxidative damage may lead to chronic inflammation, which in turn can mediate most chronic diseases including cancer, diabetes, cardiovascular, neurological, inflammatory bowel disease and pulmonary diseases. Curcumin, a yellow coloring agent extracted from turmeric, shows strong anti-oxidative and anti-inflammatory activities when used as a remedy for the prevention and treatment of chronic diseases. How oxidative stress activates inflammatory pathways leading to the progression of chronic diseases is the focus of this review. Thus, research to date suggests that chronic inflammation, oxidative stress, and most chronic diseases are closely linked, and the antioxidant properties of curcumin can play a key role in the prevention and treatment of chronic inflammation diseases.

引用

页码：9183 / 9213

页数：31

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