One-pot selective cleavage of prenyl carbamates using iodine in methanol followed by zinc

被引:8
作者
Vatèle, JM [1 ]
机构
[1] Univ Lyon 1, CNRS, UMR 5181, Lab Chim Organ 1,CPE, F-69622 Villeurbanne, France
关键词
amines; carbamates; iodine; deprotection; zinc;
D O I
10.1016/j.tetlet.2003.10.058
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The prenyloxycarbonyl (Preoc) moiety was efficiently removed from carbamates to provide the corresponding amines in good to excellent yields (63-88%) by using iodine in methanol followed by treatment of the resulting beta-methoxyiodides by zinc powder. The reaction conditions are compatible with the presence of a number of functional groups such as Boc and Cbz carbamates, sulfides, double bonds, indoles and aromatic methyl ethers. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:9127 / 9129
页数:3
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