Association of the metabolic syndrome with history of myocardial infarction and stroke in the Third National Health and Nutrition Examination Survey

被引:562
作者
Ninomiya, JK
L'Italien, G
Criqui, MH
Whyte, JL
Gamst, A
Chen, RS
机构
[1] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA
[2] Ingenix Epidemiol, Auburndale, MA USA
[3] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08543 USA
关键词
syndrome X; risk factors; myocardial infarction; stroke; epidemiology;
D O I
10.1161/01.CIR.0000108926.04022.0C
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background - The combination of cardiovascular risk factors known as the metabolic syndrome is receiving increased attention from physicians, but data on the syndrome's association with morbidity are limited. Methods and Results - Applying National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria, we evaluated 10 357 NHANES III subjects for the 5 component conditions of the metabolic syndrome: insulin resistance, abdominal obesity based on waist circumference, hypertriglyceridemia, low HDL cholesterol (HDL-C), and hypertension, as well as the full syndrome, defined as at least 3 of the 5 conditions. Logistic regression was used to estimate the cross-sectional association of the syndrome and each of its 5 component conditions separately with history of myocardial infarction (MI), stroke, and either MI or stroke (MI/stroke). Models were adjusted for age, sex, race, and cigarette smoking. The metabolic syndrome was significantly related in multivariate analysis to MI (OR, 2.01; 95% CI, 1.53 to 2.64), stroke (OR, 2.16; 95% CI, 1.48 to 3.16), and MI/stroke (OR, 2.05; 95% CI, 1.64 to 2.57). The syndrome was significantly associated with MI/stroke in both women and men. Among the component conditions, insulin resistance ( OR, 1.30; 95% CI, 1.03 to 1.66), low HDL-C (OR, 1.35; 95% CI, 1.05 to 1.74), hypertension (OR, 1.44; 95% CI, 1.00 to 2.08), and hypertriglyceridemia (OR, 1.66; 95% CI = 1.20 to 2.30) were independently and significantly related to MI/stroke. Conclusions - These results indicate a strong, consistent relationship of the metabolic syndrome with prevalent MI and stroke.
引用
收藏
页码:42 / 46
页数:5
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